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CD137 抗体

TNFRSF9 适用: 人 ELISA 宿主: 小鼠 Monoclonal h41BB unconjugated
产品编号 ABIN2688961
发货至: 中国
  • 抗原 See all CD137 (TNFRSF9) 抗体
    CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This CD137 antibody is un-conjugated
    应用范围
    • 66
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    ELISA
    品牌
    BD Pharmingen™
    产品特性
    Human 4-1BB, also known as CDw137, is a type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor (TNFR) superfamily. Naive T cells lack the 4-1BB, which is not only induced upon T cell activation, but also remains on activated T cells. It has been reported that the expression of 4-1BB is restricted to primed CD4+ and CD8+ cells. When triggered by either 4-1BB ligand or antibody ligation, the 4-1BB molecule can act as a co-stimulator to induce T-cell activation and proliferation. In recent studies, 4-1BB has been emphasized for its effect on the development and survival of functionally active effector CD8 (+) T cells against tumors, virus infections, allogenic immune responses, and for potential therapeutic application.

    BD Pharmingen™ Purified Anti-Human CD137 - Purified - Clone h41BB-M127 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    克隆位点
    H41BB
    亚型
    IgG1 kappa
    Top Product
    Discover our top product TNFRSF9 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Kim, Broxmeyer: "Therapeutic potential of 4-1BB (CD137) as a regulator for effector CD8(+) T cells." in: Journal of hematotherapy & stem cell research, Vol. 10, Issue 4, pp. 441-9, (2001) (PubMed).

    Michel, Schwarz: "Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes." in: Cytokine, Vol. 12, Issue 6, pp. 742-6, (2000) (PubMed).

    Vinay, Kwon: "Role of 4-1BB in immune responses." in: Seminars in immunology, Vol. 10, Issue 6, pp. 481-9, (1999) (PubMed).

    Melero, Shuford, Newby, Aruffo, Ledbetter, Hellström, Mittler, Chen: "Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors." in: Nature medicine, Vol. 3, Issue 6, pp. 682-5, (1997) (PubMed).

  • 抗原
    CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
    别名
    CD137 (TNFRSF9 产品)
    别名
    TNFRSF9 antibody, zgc:136557 antibody, 4-1BB antibody, CD137 antibody, CDw137 antibody, ILA antibody, A930040I11Rik antibody, AA408498 antibody, AI325004 antibody, Cd137 antibody, Ly63 antibody, tumor necrosis factor receptor superfamily member 9 antibody, TNF receptor superfamily member 9 antibody, tumor necrosis factor receptor superfamily, member 9a antibody, tumor necrosis factor receptor superfamily, member 9 antibody, TNFRSF9 antibody, tnfrsf9a antibody, Tnfrsf9 antibody
    背景
    Synonyms: 4-1BB, CDw137
    途径
    Cancer Immune Checkpoints
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