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VCAM1 抗体 (Biotin)

VCAM1 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal 429 Biotin
产品编号 ABIN2688883
发货至: 中国
  • 抗原 See all VCAM1 抗体
    VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
    适用
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    小鼠
    宿主
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    大鼠
    克隆类型
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    单克隆
    标记
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    This VCAM1 antibody is conjugated to Biotin
    应用范围
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    Flow Cytometry (FACS)
    品牌
    BD Pharmingen™
    产品特性
    The 429 antibody reacts with both the long (~110 kDa) transmembrane-spanning form and the truncated (~47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106). CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells. Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions. CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines. VCAM-1 is a counter-receptor for VLA-4 (α4β1 integrin) and LPAM-1 (α4β7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions. Source of the immunogen was mouse preadipose cell line PA6.

    BD Pharmingen™ Biotin Rat Anti-Mouse CD106 - Biotin - Clone 429 (MVCAM.A) - Isotype Rat IgG2a, κ - Reactivity Ms - 0.5 mg
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Mouse preadipose cell line PA6
    克隆位点
    429
    亚型
    IgG2a kappa
    Top Product
    Discover our top product VCAM1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
  • Koni, Joshi, Temann, Olson, Burkly, Flavell: "Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow." in: The Journal of experimental medicine, Vol. 193, Issue 6, pp. 741-54, (2001) (PubMed).

    Ishiyama, Kitagawa, Takahashi, Kina, Hirokawa: "Expression of VCAM-1 in lymphocytes during the process of apoptosis." in: Pathobiology : journal of immunopathology, molecular and cellular biology, Vol. 66, Issue 6, pp. 274-83, (1998) (PubMed).

    Kinashi, Springer: "Adhesion molecules in hematopoietic cells." in: Blood cells, Vol. 20, Issue 1, pp. 25-44, (1995) (PubMed).

    Kinashi, St Pierre, Springer: "Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells." in: Journal of leukocyte biology, Vol. 57, Issue 1, pp. 168-73, (1995) (PubMed).

    Baron, Reich, Visintin, Janeway: "The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1." in: The Journal of clinical investigation, Vol. 93, Issue 4, pp. 1700-8, (1994) (PubMed).

    Bevilacqua: "Endothelial-leukocyte adhesion molecules." in: Annual review of immunology, Vol. 11, Issue 4, pp. 767-804, (1993) (PubMed).

  • 抗原
    VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
    别名
    CD106 (VCAM1 产品)
    别名
    CD106 antibody, INCAM-100 antibody, Vcam-1 antibody, VCAM1B antibody, fi76d06 antibody, wu:fi76d06 antibody, zgc:158875 antibody, VCAM1 antibody, vascular cell adhesion molecule 1 antibody, vascular cell adhesion molecule 1b antibody, VCAM1 antibody, Vcam1 antibody, vcam1b antibody, VCAM-1 antibody
    背景
    Synonyms: VCAM-1
    途径
    Carbohydrate Homeostasis
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