IL16 抗体 (Interleukin 16)

Details for Product anti-IL16 Antibody No. ABIN2666009, 供应商: Log in to see
抗原
  • IL16
  • LCF
  • NIL16
  • PRIL16
  • prIL-16
  • mKIAA4048
  • IL-16
  • interleukin 16
  • interleukin 16 (lymphocyte chemoattractant factor)
  • IL16
  • Il16
适用

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宿主
小鼠
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克隆类型 (克隆位点)
单克隆 ()
标记
This IL16 antibody is un-conjugated
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应用范围
Flow Cytometry (FACS)
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Supplier
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Available images

品牌 Ultra-LEAF™
免疫原 AA 615 to 630 (RRKSLQSKETTAAGDS) of IL-16,615 to630 (RRKSLQSKETTAAGDS) of IL-16
克隆位点 14-1
亚型 IgG2a
交叉反应 小鼠
纯化方法 The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
过滤 0.2 μm filtered
内毒素水平

Endotoxin level is <0.01 EU/μg of the protein (<0.001 ng/μg of the protein) as determined by the LAL test.

别名 IL-16 (IL16 Antibody 摘要)
背景 Interleukin-16 is a proinflammatory cytokine synthesized as a 68 kD precursor molecule (pro-IL-16). After cleavage of pro-IL-16 by caspase-3, IL-16 is released as a 12 kD protein, but its biologic activities are exerted by a tetramer. IL-16 is a chemoattractant for CD4+ T cells, monocytes, and eosinophils. On T cells, IL-16 upregulates CD25 and class II expression, and also inhibits HIV-1 replication in vitro by repressing the transcription of the HIV-1 long terminal repeat. IL-16 is expressed by lymphocytes, macrophages, eosinophils, mast cells, epithelial cells, and fibroblasts. CD4 and CD9 are the receptors of IL-16.
研究领域 Signaling, Cytokines, Immunology, Virology, Inflammation, Cancer
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 1.0 mg/mL
储存液 Azide free
注意事项 This Ultra-LEAF™ solution contains no preservative, handle under aseptic conditions
储存条件 4 °C
储存方法 The antibody solution should be stored undiluted between 2°C and 8°C.
厂商提供的图像
Flow Cytometry (FACS) image for anti-IL16 抗体 (Interleukin 16) (ABIN2666009) anti-Interleukin 16 (IL16) antibody
背景 Bellon, Baydoun, Yao, Nicot: "HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes." in: Blood, Vol. 115, Issue 12, pp. 2441-8, 2010 (PubMed).

Cruikshank, Little: "lnterleukin-16: the ins and outs of regulating T-cell activation." in: Critical reviews in immunology, Vol. 28, Issue 6, pp. 467-83, 2009 (PubMed).

Rofani, Luchetti, Testa, Lasorella, Isacchi, Bottazzo, Berardi: "IL-16 can synergize with early acting cytokines to expand ex vivo CD34+ isolated from cord blood." in: Stem cells and development, Vol. 18, Issue 4, pp. 671-82, 2009 (PubMed).

Gu, Lewis, Deere, Groome, Wang: "Elevated maternal IL-16 levels, enhanced IL-16 expressions in endothelium and leukocytes, and increased IL-16 production by placental trophoblasts in women with preeclampsia." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 6, pp. 4418-22, 2008 (PubMed).

McFadden, Morgan, Rahangdale, Green, Yamasaki, Center, Cruikshank: "Preferential migration of T regulatory cells induced by IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 10, pp. 6439-45, 2007 (PubMed).

Qi, Wang, Mandadi, Tanaka, Roufogalis, Madigan, Lai, Yan, Chong, Stevens, Krilis: "Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor." in: Blood, Vol. 107, Issue 1, pp. 135-42, 2005 (PubMed).

Ren, Zhan, Martens, Lee, Center, Hanson, Kornfeld: "Pro-IL-16 regulation in activated murine CD4+ lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 5, pp. 2738-45, 2005 (PubMed).

Stoitzner, Ratzinger, Koch, Janke, Schöller, Kaser, Tilg, Cruikshank, Fritsch, Romani: "Interleukin-16 supports the migration of Langerhans cells, partly in a CD4-independent way." in: The Journal of investigative dermatology, Vol. 116, Issue 5, pp. 641-9, 2001 (PubMed).

Chupp, Wright, Wu, Vallen-Mashikian, Cruikshank, Center, Kornfeld, Berman: "Tissue and T cell distribution of precursor and mature IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 6, pp. 3114-9, 1998 (PubMed).

Keane, Nicoll, Kim, Wu, Cruikshank, Brazer, Natke, Zhang, Center, Kornfeld: "Conservation of structure and function between human and murine IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 12, pp. 5945-54, 1998 (PubMed).

Cruikshank, Center, Nisar, Wu, Natke, Theodore, Kornfeld: "Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 11, pp. 5109-13, 1994 (PubMed).