Interleukin 33 抗体 (IL33) (AA 112-270)

Details for Product anti-IL33 Antibody No. ABIN2665497, 供应商: Log in to see
抗原
  • IL33
  • C9orf26
  • DVS27
  • IL1F11
  • NF-HEV
  • NFEHEV
  • RP11-575C20.2
  • 9230117N10Rik
  • Il-33
  • Il1f11
  • RGD1311155
  • interleukin 33
  • interleukin 33-like
  • interleukin-33-like
  • IL33
  • Il33
  • LOC100356081
  • LOC100518643
抗原表位
AA 112-270
71
26
26
20
12
7
6
5
5
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
适用

293
118
48
8
4
3
2
2
宿主
山羊
191
133
34
25
4
3
2
1
1
克隆类型 (克隆位点)
多克隆 ()
标记
This Interleukin 33 antibody is un-conjugated
37
19
16
14
9
9
6
6
5
4
4
4
4
4
4
3
3
3
3
3
3
3
1
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS), Immunohistochemistry (IHC)
285
216
90
73
45
26
22
21
16
14
13
11
7
6
5
5
4
4
3
2
2
2
1
选项
Supplier
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Supplier Product No.
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免疫原 AA 112-270 (Accession# NM_033439) was expressed in E. coli.
克隆位点 Poly5163
亚型 Ig Fraction, IgG
交叉反应 (详细) In sandwich ELISA, no cross-reactivity with mouse or rat IL-33.
纯化方法 The antibody was purified by antigen affinity chromatography.
别名 IL-33 (IL33 Antibody 摘要)
背景 IL-33, also known as NFHEV and DVS 27, is a 30 kD proinflammatory protein that belongs to IL-1 superfamily. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1α or IL-1β stimulation. IL-33 interacts with IL1RL1/ST2 receptor and IL-1 receptor accessory protein (IL1RAP) in order to activate intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. Recombinant IL-33 has been shown to enhance Th2-associated immune responses and potently increase mast cell proliferation and cytokine production.
途径 Production of Molecular Mediator of Immune Response
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 0.5 mg/mL
缓冲液 Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Do not freeze.
储存条件 4 °C
储存方法 The antibody solution should be stored undiluted between 2°C and 8°C.
厂商提供的图像
ELISA image for anti-Interleukin 33 (IL33) (AA 112-270) antibody (ABIN2665497) anti-Interleukin 33 (IL33) (AA 112-270) antibody
背景 McLaren, Michael, Salter, Ashlin, Calder, Miller, Liew, Ramji: "IL-33 reduces macrophage foam cell formation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 2, pp. 1222-9, 2010 (PubMed).

Schmitz, Owyang, Oldham, Song, Murphy, McClanahan, Zurawski, Moshrefi, Qin, Li, Gorman, Bazan, Kastelein: "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines." in: Immunity, Vol. 23, Issue 5, pp. 479-90, 2005 (PubMed).

Onda, Kasuya, Takakura, Hori, Imaizumi, Takeuchi, Inoue, Takeda: "Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 19, Issue 11, pp. 1279-88, 1999 (PubMed).

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