Interleukin 22 (IL22) (Ala34) 抗体

ABIN2665496 产品详细信息, 供应商: Log in to see
抗原
  • IL-17D
  • IL-22
  • IL-27
  • IL27
  • IL-21
  • IL-D110
  • IL-TIF
  • ILTIF
  • TIFIL-23
  • TIFa
  • zcyto18
  • IL-22a
  • ILTIFa
  • Iltif
  • RGD1561292
  • interleukin-22
  • interleukin 22
  • interleukin 17D
  • il22
  • IL17D
  • IL22
  • Il22
  • LOC100348980
  • IL-22
抗原表位
Ala34
44
13
12
9
8
5
3
3
3
3
1
1
1
1
1
适用

218
118
32
2
2
2
2
1
1
1
1
1
宿主
山羊
130
106
50
13
克隆类型 (克隆位点)
多克隆 ()
标记
非结合性
32
17
12
10
10
10
9
8
8
7
6
6
6
6
6
6
6
4
3
3
3
3
2
1
1
1
1
1
1
1
1
1
应用范围
Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
219
92
62
31
19
13
11
8
6
5
3
3
2
2
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

免疫原 Ala34-Isoleucin179 (Accession# NM_020525) was expressed in E. coli.
克隆位点 Poly5161
亚型 Ig Fraction, IgG
交叉反应 (详细) In sandwich ELISA, less than 10 % cross-reactivity with recombinant mouse IL-22.
纯化方法 The antibody was purified by antigen affinity chromatography.
别名 IL-22 (IL22 Antibody 摘要)
背景 IL-22 is a cytokine structurally related to IL-10. Originally identified as a murine gene induced by IL-9 in T and mast cells, IL-22 was initially designated ILTIF (IL-10-related T cell-derived inducible factor). IL-22 belongs to a family of cytokines with limited homology to IL-10, namely IL-10, IL-19, IL-20, IL-24, IL-26, and the IFN-λs, IL-28A, IL-28B and IL-29. Human IL-22 shares 79 % amino acid identity with murine IL-22 and 25 % identity with human IL-10. IL-22 biological activity is initiated by binding to a cell surface complex composed of IL-22R1 and IL-10R2 receptor chains. Activity is further regulated through interactions with the soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). Both chains of the IL-22R complex belong to the class II CRF. Two types of IL-22 binding receptors have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes. IL-22 is produced by Th17 cells and newly identified Th22 cells. It plays a critical role in mucosal immunity in addition to the deregulated inflammation observed in autoimmune diseases.
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 0.5 mg/mL
缓冲液 Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Do not freeze.
储存条件 4 °C
储存方法 The antibody solution should be stored undiluted between 2°C and 8°C.
厂商提供的图像
ELISA image for anti-Interleukin 22 (IL22) (Ala34) 抗体 (ABIN2665496) anti-Interleukin 22 (IL22) (Ala34) antibody
背景 Trifari, Kaplan, Tran, Crellin, Spits: "Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells." in: Nature immunology, Vol. 10, Issue 8, pp. 864-71, 2009 (PubMed).

Gu, Yang, Ouyang, Liu, Li, Yang, Bromberg, Chen, Mayer, Unkeless, Xiong: "Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells." in: European journal of immunology, Vol. 38, Issue 7, pp. 1807-13, 2008 (PubMed).

Pène, Chevalier, Preisser, Vénéreau, Guilleux, Ghannam, Molès, Danger, Ravon, Lesaux, Yssel, Gascan: "Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 11, pp. 7423-30, 2008 (PubMed).

Kebir, Kreymborg, Ifergan, Dodelet-Devillers, Cayrol, Bernard, Giuliani, Arbour, Becher, Prat: "Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation." in: Nature medicine, Vol. 13, Issue 10, pp. 1173-5, 2007 (PubMed).

Chung, Yang, Chang, Ma, Tian, Dong: "Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes." in: Cell research, Vol. 16, Issue 11, pp. 902-7, 2006 (PubMed).

Nagalakshmi, Rascle, Zurawski, Menon, de Waal Malefyt: "Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells." in: International immunopharmacology, Vol. 4, Issue 5, pp. 679-91, 2004 (PubMed).

Kotenko, Izotova, Mirochnitchenko, Esterova, Dickensheets, Donnelly, Pestka: "Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 12, pp. 7096-103, 2001 (PubMed).

Dumoutier, Louahed, Renauld: "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1814-9, 2000 (PubMed).