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CCL28 抗体

CCL28 适用: 人 FACS, CyTOF 宿主: 小鼠 Monoclonal J132C3 unconjugated
产品编号 ABIN2664098
发货至: 中国
  • 抗原 See all CCL28 抗体
    CCL28 (Chemokine (C-C Motif) Ligand 28 (CCL28))
    适用
    • 19
    • 5
    • 2
    宿主
    • 19
    • 2
    小鼠
    克隆类型
    • 20
    • 1
    单克隆
    标记
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CCL28 antibody is un-conjugated
    应用范围
    • 15
    • 7
    • 4
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)
    纯化方法
    The antibody was purified by affinity chromatography.
    克隆位点
    J132C3
    亚型
    IgG2b kappa
    Top Product
    Discover our top product CCL28 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    CCL28 (Chemokine (C-C Motif) Ligand 28 (CCL28))
    别名
    CCL28 (CCL28 产品)
    别名
    Scya28 antibody, CCL28 antibody, ccl28 antibody, nrpb antibody, enc-1 antibody, pig10 antibody, Encr-3 antibody, klhl35 antibody, Xencr-3 antibody, tp53i10 antibody, LOC100303767 antibody, CCK1 antibody, MEC antibody, SCYA28 antibody, C-C motif chemokine ligand 28 antibody, ectodermal-neural cortex 1 (with BTB domain) antibody, C-C motif chemokine 28 antibody, chemokine (C-C motif) ligand 28 antibody, Ccl28 antibody, CCL28 antibody, ccl28 antibody, enc1 antibody, LOC100303767 antibody
    背景
    Human CCL28 was identified in an EST database using a human chemokine consensus sequence. CCL28 is constitutively expressed by mucosal epithelial cells such as exocrine glands, trachea, and colon. Acinar epithelial cells in human and mouse salivary glands are strongly positive for CCL28 by immunostaining, and human saliva and milk contain high concentrations of CCL28. Furthermore, it is known that human and mouse CCL28 have antimicrobial activity attributed to the C-terminus of CCL28 against Candida albicans, Gram-negative bacteria, and Gram-positive bacteria. In addition, using a CCR10 deficient mouse model, it was shown that CCR10 plays a critical role in localization and accumulation of IgA ASC in lactating mammary glands. Also, it has been described that CCL28 is upregulated in epithelial inflammation, and this upregulation allows the recruitment of Tregs expressing CCR10. In fact, a subpopulation of CCR10-expressing CD25+CD4+FOXP3+ Tregs with potent anti-inflammatory properties was isolated from a chronically inflamed human liver. Information suggests that tumor hypoxia promotes the recruitment of Tregs through induction of expression of CCL28, and this induction is mediated by the hypoxia inducible factor-1α (HIF-1α). Therefore, tumor hypoxia promotes tolerance and angiogenesis via CCL28 and Tregs.
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