Interleukin 22 (IL22) (AA 34-179) 抗体 (PE)

ABIN2663784 产品详细信息, 供应商: Log in to see
抗原
  • IL-17D
  • IL-22
  • IL-27
  • IL27
  • IL-21
  • IL-D110
  • IL-TIF
  • ILTIF
  • TIFIL-23
  • TIFa
  • zcyto18
  • IL-22a
  • ILTIFa
  • Iltif
  • RGD1561292
  • interleukin-22
  • interleukin 22
  • interleukin 17D
  • il22
  • IL17D
  • IL22
  • Il22
  • LOC100348980
  • IL-22
抗原表位
AA 34-179
43
13
12
9
8
5
3
3
3
3
2
1
1
1
1
适用
小鼠
219
117
32
2
2
2
2
1
1
1
1
1
宿主
山羊
130
106
50
13
克隆类型 (克隆位点)
多克隆 ()
标记
PE
32
16
12
10
10
10
9
8
8
7
6
6
6
6
6
6
6
4
3
3
3
3
2
1
1
1
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS)
220
92
62
31
20
13
11
8
6
5
3
3
2
2
2
1
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免疫原 AA 34-179 (Accession# NM_016971), was expressed in E. coli.
克隆位点 Poly5164
亚型 IgG
纯化方法 The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
别名 IL-22 (IL22 Antibody 摘要)
背景 IL-22 is a cytokine structurally related to IL-10. Mouse IL-22 consists of 179 amino acids and has a predicted molecular weight of 20 kD. It is secreted primarily by Th17, Th1, Th2, lymphoid tissue inducer cells (LTi), and subsets of natural killer cells. It has been reported that aryl hydrocarbon receptor (AhR) expression is essential for the production of IL-22 by TCRγδ T cells. AhR activation increases Th17 polarization and induces IL-22 production. IL-22 functions by engaging the heterodimeric IL-22 receptor (IL-22R) complex, consisting of two receptor subunits, IL-22R1 and IL-10Rβ. IL-22 acts on nonhematopoietic tissue cells, such as epithelial cells of the digestive and respiratory systems and keratinocytes of the skin. IL-22 is involved in inflammatory processes such as dermal inflammation, psoriasis, inflammatory bowel disease, hepatitis, and Crohn's disease. Moreover, it plays a critical role in mucosal immunity and the wound healing process.
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
缓冲液 Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Protect from prolonged exposure to light. Do not freeze.
储存条件 4 °C
储存方法 The antibody solution should be stored undiluted between 2°C and 8°C.
厂商提供的图像
Flow Cytometry (FACS) image for anti-Interleukin 22 (IL22) (AA 34-179) 抗体 (PE) (ABIN2663784) anti-Interleukin 22 (IL22) (AA 34-179) antibody (PE)
Flow Cytometry (FACS) image for anti-Interleukin 22 (IL22) (AA 34-179) 抗体 (PE) (ABIN2663784) anti-Interleukin 22 (IL22) (AA 34-179) antibody (PE) (Image 2)
背景 Zhao, Zhu, Ye, Li, Wang, Zhang, Xu: "The potential protective role of the combination of IL-22 and TNF-α against genital tract Chlamydia trachomatis infection." in: Cytokine, Vol. 73, Issue 1, pp. 66-73, 2015 (PubMed).

Martin, Hirota, Cua, Stockinger, Veldhoen: "Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals." in: Immunity, Vol. 31, Issue 2, pp. 321-30, 2009 (PubMed).

Veldhoen, Hirota, Christensen, OGarra, Stockinger: "Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells." in: The Journal of experimental medicine, Vol. 206, Issue 1, pp. 43-9, 2009 (PubMed).

Wolk, Witte, Hoffmann, Doecke, Endesfelder, Asadullah, Sterry, Volk, Wittig, Sabat: "IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 9, pp. 5973-81, 2007 (PubMed).

Zheng, Danilenko, Valdez, Kasman, Eastham-Anderson, Wu, Ouyang: "Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis." in: Nature, Vol. 445, Issue 7128, pp. 648-51, 2007 (PubMed).

Liang, Tan, Luxenberg, Karim, Dunussi-Joannopoulos, Collins, Fouser: "Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides." in: The Journal of experimental medicine, Vol. 203, Issue 10, pp. 2271-9, 2006 (PubMed).

Dumoutier, Louahed, Renauld: "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1814-9, 2000 (PubMed).