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- 抗原 See all IL21 Receptor (IL21R) 抗体
- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IL21 Receptor antibody is conjugated to PE
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应用范围
- Biochemical Assay (BCA)
- 交叉反应
- Cynomolgus, 猕猴
- 纯化方法
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
- 克隆位点
- 2G1-K12
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product IL21R Primary Antibody
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anti-Interleukin 21 Receptor (IL21R) (AA 20-232) antibody
IL21R 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 8H10G4D12 unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 20-240) antibodyIL21R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 97-111) antibodyIL21R 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 441-538) antibodyIL21R 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 20-240) antibodyIL21R 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 131-165) antibodyIL21R 适用: 人 WB 宿主: 兔 Polyclonal RB54166 unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 35-65), (N-Term) antibodyIL21R 适用: 人 ELISA, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 65-80) antibodyIL21R 适用: 人, 猴 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 65-80) antibodyIL21R 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 21 Receptor (IL21R) (AA 23-185) antibodyIL21R 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Protect from prolonged exposure to light. Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- 抗原
- IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))
- 别名
- CD360 (IL21R 产品)
- 别名
- IL21R antibody, il-21ra.a antibody, CD360 antibody, NILR antibody, interleukin 21 receptor antibody, interleukin 21 receptor, tandem duplicate 1 antibody, IL21R antibody, il21r.1 antibody, Il21r antibody
- 背景
- The human interleukin 21 receptor (IL-21R), is a single pass type I membrane protein and a member of the type I cytokine receptor family. Of the type I cytokine receptors, IL-21R exhibits the greatest extracellular homology to the IL-2R beta subunit, i.e., contains one copy of the WSXWS-containing cytokine-binding domain. Intracellular domains of IL-21R include the Box 1 and Box 2 elements which are similar to the IL-9R intracellular region. Upon binding IL-21, the IL-21R forms a heterodimer with the common gamma subunit (CD132) and induces Jak/Stat signaling. IL-21R is expressed on B cells and at various levels on NK and T cells. IL-21 is a potent immunomodulatory cytokine mainly produced by NKT and CD4 T-cells (particularly the inflammatory Th17 subset) and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhanced proliferation of natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells and direct inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
- 途径
- JAK/STAT Signaling
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