Tumor Necrosis Factor 抗体 (TNF) (Pacific Blue)

Details for Product anti-TNF Antibody No. ABIN2662374, 供应商: Log in to see
抗原
  • TNF
  • tnf
  • dif
  • tnfa
  • xtnf
  • TNF-a
  • tnfsf2
  • tnf-alpha
  • TNF-alpha
  • DIF
  • TNFA
  • TNFSF2
  • TNFalpha
  • Tnfa
  • Tnfsf1a
  • RATTNF
  • TNFa
  • cTNF
  • TNF-ALPHA
  • Cachectin
  • Tnf-alpha
  • tnfa-like
  • tumor necrosis factor (TNF superfamily, member 2)
  • tumor necrosis factor
  • tumour necrosis factor alpha-like
  • tumor necrosis factor alpha
  • lipopolysaccharide-induced TNF factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • TNF
  • tnf
  • tnf-alpha
  • LITAF
  • Tnf
  • tnfb
Alternatives
anti-人 Tumor Necrosis Factor 抗体 for Activity Inhibition
适用

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宿主
小鼠
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克隆类型 (克隆位点)
单克隆 ()
标记
This Tumor Necrosis Factor antibody is conjugated to Pacific Blue
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应用范围
Flow Cytometry (FACS)
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Supplier
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克隆位点 MAb11
亚型 IgG1 kappa
交叉反应 Chimpanzee, Baboon, Cynomolgus, 猕猴, 猪, Pigtailed Macaque, Sooty mangabey (Cercocebus atys)
纯化方法 The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions. The solution is free of unconjugated Pacific Blue™.
别名 TNF-alpha (TNF Antibody 摘要)
背景 TNF-α is secreted by macrophages, monocytes, neutrophils, T cells (principally CD4+), and NK cells. Many transformed cell lines also secrete TNF-α. Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kD. TNF-α forms multimeric complexes, stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biological activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.
研究领域 Inflammation, Cancer, Virology
途径 NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 0.5 mg/mL
缓冲液 Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Protect from prolonged exposure to light. Do not freeze.
储存条件 4 °C
储存方法 The antibody solution should be stored undiluted between 2°C and 8°C.
厂商提供的图像
Flow Cytometry (FACS) image for anti-Tumor Necrosis Factor 抗体 (TNF)  (Pacific Blue) (ABIN2662374) anti-Tumor Necrosis Factor (TNF) antibody (Pacific Blue)
Flow Cytometry (FACS) image for anti-Tumor Necrosis Factor 抗体 (TNF)  (Pacific Blue) (ABIN2662374) anti-Tumor Necrosis Factor (TNF) antibody (Pacific Blue) (Image 2)
背景 Braun, Björkström, Gupta, Sundström, Ahlm, Klingström, Ljunggren: "NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Rα expression." in: PLoS pathogens, Vol. 10, Issue 11, pp. e1004521, 2014 (PubMed).

Iwamoto, Iwai, Tsujiyama, Kurahashi, Takeshita, Naoe, Masunaga, Ogawa, Oguchi, Miyazaki: "TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 3, pp. 1449-57, 2007 (PubMed).

Chen, Hou, Jiang, Ma, Meng, Wang, Zhang, Zhang, Tang, Zhang, Wan, Li, Yu, Hu, Yang, He, Wang, Cao: "Response of memory CD8+ T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 1, pp. 591-8, 2005 (PubMed).

Enríquez, Klínger, Arturo, Delgado, Tobar, Mosquera: "Peritonitis in continuous ambulatory peritoneal dialysis: cytokines in peritoneal fluid and blood." in: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, Vol. 18, pp. 177-83, 2002 (PubMed).

Andersson, Wang, Palmblad, Aveberger, Bloom, Erlandsson-Harris, Janson, Kokkola, Zhang, Yang, Tracey: "High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes." in: The Journal of experimental medicine, Vol. 192, Issue 4, pp. 565-70, 2001 (PubMed).

Moormann, Sullivan, Rochford, Chensue, Bock, Nyirenda, Meshnick: "Malaria and pregnancy: placental cytokine expression and its relationship to intrauterine growth retardation." in: The Journal of infectious diseases, Vol. 180, Issue 6, pp. 1987-93, 2000 (PubMed).

Tracey, Cerami: "Tumor necrosis factor: an updated review of its biology." in: Critical care medicine, Vol. 21, Issue 10 Suppl, pp. S415-22, 1993 (PubMed).

Rathjen, Cowan, Furphy, Aston: "Antigenic structure of human tumour necrosis factor: recognition of distinct regions of TNF alpha by different tumour cell receptors." in: Molecular immunology, Vol. 28, Issue 1-2, pp. 79-86, 1991 (PubMed).

Danis, Franic, Rathjen, Brooks et al.: "Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-2, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 ..." in: Clinical and experimental immunology, Vol. 85, Issue 1, pp. 143-50, 1991 (PubMed).

Beutler, Cerami: "The biology of cachectin/TNF--a primary mediator of the host response." in: Annual review of immunology, Vol. 7, pp. 625-55, 1989 (PubMed).

Beutler, Cerami: "Tumor necrosis, cachexia, shock, and inflammation: a common mediator." in: Annual review of biochemistry, Vol. 57, pp. 505-18, 1988 (PubMed).