Thymic Stromal Lymphopoietin 抗体 (AA 29-159) (Biotin)
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- 抗原 See all Thymic Stromal Lymphopoietin (TSLP) 抗体
- Thymic Stromal Lymphopoietin (TSLP)
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抗原表位
- AA 29-159
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适用
- 人
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宿主
- 山羊
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克隆类型
- 多克隆
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标记
- This Thymic Stromal Lymphopoietin antibody is conjugated to Biotin
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应用范围
- ELISA (Detection)
- 交叉反应 （详细）
- Not cross-reactive with recombinant mouse TSLP.
- 纯化方法
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
- 免疫原
- AA 29-159 (Accession# AF338732), was expressed in E.coli.
- 克隆位点
- Poly5159
- 亚型
- Ig Fraction, IgG
- Top Product
- Discover our top product TSLP Primary Antibody
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anti-Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) antibody
TSLP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) antibodyTSLP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) antibodyTSLP 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C5 unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 101-159) antibodyTSLP 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) antibodyTSLP 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 21-138) antibodyTSLP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 89-138) antibodyTSLP 适用: 人, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) antibody (Biotin)TSLP 适用: 人 WB, ELISA 宿主: 兔 Polyclonal Biotin
anti-Thymic Stromal Lymphopoietin (TSLP) antibodyTSLP 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 75-196) antibodyTSLP 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.2 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 1 % BSA and 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- 抗原
- Thymic Stromal Lymphopoietin (TSLP)
- 别名
- TSLP (TSLP 产品)
- 别名
- TSLP antibody, thymic stromal lymphopoietin antibody, TSLP antibody, Tslp antibody
- 背景
- TSLP was initially identified in conditioned medium from a mouse thymic stromal cell line. Human and mouse TSLP are only 43 % identical at the amino acid level, and TSLP, like IL-7, exhibits species-specific functions and may function differently in humans and mice. TSLP binds to a heterodimeric receptor constituted by IL-7Ra and TSLPR. TSLPR has low affinity for TSLP, but in combination with IL-7Ra generates a high affinity binding site. TSLP has been associated with the development of allergic disorders in humans, such as asthma, atopic dermatitis, and food allergies. The susceptibility to allergic diseases has been associated to basophil induction by TSLP, and Th2 cytokine production induced by TSLP in mast cells. In addition, TSLP has been associated to the development of Tregs, and blocking TSLPR leads to delayed functional maturation of thymic Tregs. TSLPR has been detected in Tregs from allergic asthmatic patients. TSLP directly activates STAT5 in Tregs and suppresses its suppressive activities, additionally, it inhibits IL-10 production. Human TSLP induces the release of T cell-attracting chemokines (CCL17 and CCL22) from monocytes and enhances the T cell stimulatory capacity of the CD11c+ subset of dendritic cells. TSLP induces proliferation of naive T cells. In addition, it can drive Th2 differentiation via the induction of IL-4 production, and drives Th2 cytokine-mediated inflammation by acting on bone marrow-resident progenitors, which promotes basophil hematopoiesis. TSLP is upregulated in epithelial cells by IL-1α, TNFα, and Th2 cytokines.
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