BCL2 抗体 (B-Cell CLL/lymphoma 2) (AA 41-54) (Alexa Fluor 647)

Details for Product anti-BCL2 Antibody No. ABIN2657117, 供应商: Log in to see
抗原
  • Bcl-2
  • PPP1R50
  • bcl-2
  • AW986256
  • C430015F12Rik
  • D630044D05Rik
  • D830018M01Rik
  • BCL-2
  • Bcl2
  • B-cell CLL/lymphoma 2
  • B cell leukemia/lymphoma 2
  • B-cell leukemia/lymphoma 2
  • B-cell leukemia/lymphoma 2-like
  • B-cell CLL/lymphoma 2 protein
  • BCL2
  • Bcl2
  • LOC100224888
  • bcl2
  • LOC100359045
  • BCL-2
抗原表位
AA 41-54
163
78
67
65
44
31
25
25
24
21
18
15
15
15
13
13
13
11
9
9
6
6
6
5
5
5
5
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用

1060
258
213
54
28
22
18
18
5
4
4
3
2
2
2
2
宿主
小鼠
578
547
19
6
2
2
2
克隆类型 (克隆位点)
单克隆 ()
标记
This BCL2 antibody is conjugated to Alexa Fluor 647
50
50
45
38
24
24
22
16
15
14
14
14
14
14
14
14
13
13
13
7
7
7
6
6
6
6
6
6
6
2
2
1
1
1
1
1
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS), Immunoprecipitation (IP)
839
398
388
342
335
327
234
195
171
81
40
15
14
13
12
11
9
4
3
2
1
1
1
1
1
1
1
选项
Supplier
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Supplier Product No.
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免疫原 AA 41-54 of human bcl-2 oncoprotein
克隆位点 100
亚型 IgG1
纯化方法 The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
别名 Bcl-2 (BCL2 Antibody 摘要)
背景 Bcl-2 is a conserved anti-apoptotic protein that plays important roles in normal immunity. It forms homodimers or heterodimers with other Bcl-2 family members. This protein regulates apoptosis through controlling mitochondrial fusion and fission. Phosphorylation of Bcl-2 has been shown to enhance activity to allow response to extracellular growth-factor-mediated signals. Bcl-2 is also regulated by IRES, miR-15a, miR-16-1 and RNA-BP nucleolin. Chromosome 18q21.3 translocation and overexpression of Bcl-2 is frequently observed in follicular lymphomas and some diffuse large B-cell lymphomas.
研究领域 Cancer, Apoptosis/Necrosis
途径 MAPK Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
缓冲液 Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Protect from prolonged exposure to light. Do not freeze.
储存条件 4 °C
储存方法 The antibody solution should be stored undiluted between 2°C and 8°C
厂商提供的图像
Flow Cytometry (FACS) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody (Alexa Fluor 647) (ABIN2657117) anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody (Alexa Fluor 647)
背景 Lin, Medeiros: "The impact of MYC rearrangements and "double hit" abnormalities in diffuse large B-cell lymphoma." in: Current hematologic malignancy reports, Vol. 8, Issue 3, pp. 243-52, 2013 (PubMed).

Kelly, Strasser: "The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy." in: Cell death and differentiation, Vol. 18, Issue 9, pp. 1414-24, 2011 (PubMed).

Tomita: "BCL2 and MYC dual-hit lymphoma/leukemia." in: Journal of clinical and experimental hematopathology : JCEH, Vol. 51, Issue 1, pp. 7-12, 2011 (PubMed).

Rolland, Conradt: "New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics." in: Current opinion in cell biology, Vol. 22, Issue 6, pp. 852-8, 2010 (PubMed).

Willimott, Wagner: "Post-transcriptional and post-translational regulation of Bcl2." in: Biochemical Society transactions, Vol. 38, Issue 6, pp. 1571-5, 2010 (PubMed).

Pezzella, Turley, Kuzu, Tungekar, Dunnill, Pierce, Harris, Gatter, Mason: "bcl-2 protein in non-small-cell lung carcinoma." in: The New England journal of medicine, Vol. 329, Issue 10, pp. 690-4, 1993 (PubMed).

Pezzella, Tse, Cordell, Pulford, Gatter, Mason: "Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation." in: The American journal of pathology, Vol. 137, Issue 2, pp. 225-32, 1990 (PubMed).

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