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NFATC1 抗体 (AA 197-304) (Alexa Fluor 488)

NFATC1 适用: 人, 小鼠, 大鼠 FACS, CyTOF 宿主: 小鼠 Monoclonal 7A6 Alexa Fluor 488
产品编号 ABIN2657093
发货至: 中国
  • 抗原 See all NFATC1 抗体
    NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1))
    抗原表位
    • 16
    • 11
    • 10
    • 10
    • 9
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 197-304
    适用
    • 106
    • 47
    • 25
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 98
    • 7
    • 1
    小鼠
    克隆类型
    • 91
    • 15
    单克隆
    标记
    • 45
    • 8
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NFATC1 antibody is conjugated to Alexa Fluor 488
    应用范围
    • 59
    • 36
    • 29
    • 18
    • 13
    • 13
    • 8
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)
    纯化方法
    The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
    克隆位点
    7A6
    亚型
    IgG1
    Top Product
    Discover our top product NFATC1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Protect from prolonged exposure to light. Do not freeze.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C
  • 抗原
    NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1))
    别名
    NFATc1 (NFATC1 产品)
    背景
    The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. The protein complex consists of NFAT1, NFAT2 (NFATc1 or NFATc), NFAT3, and NFAT4. All members of this family are transcription factors with a Rel homology domain and regulate gene transcription in concert with AP-1 (Jun/Fos) to orchestrate an effective immune response. NFAT proteins are predominantly expressed in cells of the immune system but are also expressed in skeletal muscle, keratinocytes and adipocytes, regulating cell differentiation programs in these cells. In resting cells, NFAT proteins are heavily phosphorylated and localized in the cytoplasm. Increased intracellular calcium concentrations activate the calcium/calmodulin-dependent serine phosphatase calcineurin, which dephosphorylates NFAT proteins, resulting in their subsequent translocation to the nucleus. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
    途径
    RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway
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