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SH2D1A 抗体

SH2D1A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN265020
发货至: 中国
  • 抗原 See all SH2D1A 抗体
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    适用
    • 50
    • 19
    • 19
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 46
    • 3
    • 1
    • 1
    克隆类型
    • 49
    • 2
    多克隆
    标记
    • 23
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This SH2D1A antibody is un-conjugated
    应用范围
    • 46
    • 20
    • 13
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    特异性
    This antibody reacts to SH2D1A.
    纯化方法
    Purified
    免疫原
    Full-length recombinant SAP protein
    亚型
    IgG
    Top Product
    Discover our top product SH2D1A Primary Antibody
  • 应用备注
    Western Blot: 5 - 10 μg/mL. Immunoprecipitation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    Phosphate buffered saline with 0.08 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • 抗原
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    别名
    SH2D1A (SH2D1A 产品)
    别名
    DSHP antibody, EBVS antibody, IMD5 antibody, LYP antibody, MTCP1 antibody, SAP antibody, SAP/SH2D1A antibody, XLP antibody, XLPD antibody, RGD1562408 antibody, Gm686 antibody, SH2D1A antibody, SH2 domain containing 1A antibody, SH2D1A antibody, Sh2d1a antibody
    背景
    SLAM (Signaling Lymphocyte-Activation Molecule) is a glycosylated type-I transmembrane protein which is present on the surface of B and T cells. SLAM is a high-affinity self-ligand which, when triggered, co-activated B or T lymphocyte responses and is considered to be important in bi-directional T - B cell stimulation. SAP (SLAM-Associated Protein) has been determined to be a 15 kDa protein. SAP is believed to the genetic defect which cauases X-linked Lymphoproliferative Syndrome (XLP). SAP is thought to bind to SLAM by the SH2 domain of the SAP protein. Binding of SAP to the SLAM protein blocks the binding of SHP-2 to the phosphorylated SLAM protein which causes XLP.Synonyms: DSHP, Duncan disease SH2-protein, SAP, SH2 domain-containing protein 1A, SLAM-associated protein, Signaling lymphocytic activation molecule-associated protein, T-cell signal transduction molecule SAP
    基因ID
    4068
    NCBI登录号
    NP_001108409
    UniProt
    O60880
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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