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BACE1 抗体 (AA 485-501)

BACE1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN264995
发货至: 中国
  • 抗原 See all BACE1 抗体
    BACE1 (Beta-secretase 1 (BACE1))
    抗原表位
    • 16
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    AA 485-501
    适用
    • 82
    • 51
    • 41
    • 7
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    • 5
    • 5
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    • 5
    • 4
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    • 1
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    人, 小鼠
    宿主
    • 76
    • 11
    克隆类型
    • 71
    • 16
    多克隆
    标记
    • 56
    • 4
    • 4
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    • 2
    • 2
    • 2
    • 2
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    • 2
    • 1
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    This BACE1 antibody is un-conjugated
    应用范围
    • 64
    • 37
    • 29
    • 18
    • 14
    • 13
    • 13
    • 11
    • 11
    • 7
    • 3
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    Western Blotting (WB)
    特异性
    This antibody Detects BACE (CT).
    纯化方法
    Purified
    免疫原
    Synthetic peptide corresponding to amino acids 485 to 501 of Human BACE.
    亚型
    IgG
    Top Product
    Discover our top product BACE1 Primary Antibody
  • 应用备注
    Western Blot: 0.5-1.0 μg/mL. Detects an approximately 70 kDa band. Positive Control: Human brain tissue lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    Phosphate buffered saline solution containing 0.02 % Sodium Azide as a preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • 抗原
    BACE1 (Beta-secretase 1 (BACE1))
    别名
    BACE1 (BACE1 产品)
    别名
    ASP2 antibody, BACE antibody, HSPC104 antibody, C76936 antibody, Bace antibody, MGC145931 antibody, BACE1 antibody, zgc:77409 antibody, beta-secretase 1 antibody, beta-site APP cleaving enzyme 1 antibody, beta-site APP-cleaving enzyme 1 antibody, BACE1 antibody, Bace1 antibody, bace1 antibody
    背景
    BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide.Synonyms: ASP2, Aspartyl protease 2, BACE, BACE-1, Beta-secretase 1, Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2
    基因ID
    23621
    NCBI登录号
    NP_036236
    UniProt
    P56817
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