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PUMA 抗体 (C-Term)

BBC3 适用: 人, 大鼠, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN264891
发货至: 中国
  • 抗原 See all PUMA (BBC3) 抗体
    PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
    抗原表位
    • 21
    • 18
    • 16
    • 10
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 114
    • 40
    • 39
    • 16
    人, 大鼠, 小鼠
    宿主
    • 110
    • 7
    • 1
    克隆类型
    • 99
    • 19
    多克隆
    标记
    • 53
    • 8
    • 8
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PUMA antibody is un-conjugated
    应用范围
    • 99
    • 40
    • 39
    • 23
    • 22
    • 17
    • 16
    • 14
    • 13
    • 9
    • 5
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    特异性
    This antibody detects a 23 kDa protein corresponding to the molecular mass of PUMA on SDS PAGE immunoblots. 16 kDa band may be seen in some instances, possibly corresponding to PUMAβ.
    纯化方法
    Affinity Chromatography
    免疫原
    C-terminal amino acids of Human PUMA
    亚型
    IgG
    Top Product
    Discover our top product BBC3 Primary Antibody
  • 应用备注
    Western blot: 1: 1000. Immunoflourescence: 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.0 mg/mL
    缓冲液
    PBS, 0.02 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
    别名
    PUMA (BBC3 产品)
    别名
    BBC3 antibody, Puma antibody, JFY-1 antibody, JFY1 antibody, PUMA antibody, PUMA/JFY1 antibody, BCL2 binding component 3 antibody, Bcl-2 binding component 3 antibody, BBC3 antibody, Bbc3 antibody, bbc3 antibody
    背景
    Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.Synonyms: BBC3, Bcl-2-binding component 3, JFY-1, p53 up-regulated modulator of apoptosis
    基因ID
    27113
    NCBI登录号
    NP_001120712
    UniProt
    Q9BXH1
    途径
    p53 Pathway, Positive Regulation of Endopeptidase Activity
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