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Caspase 8 抗体

CASP8 适用: 人 WB 宿主: 小鼠 Monoclonal FLICE 1 1-37 unconjugated
产品编号 ABIN264407
发货至: 中国
  • 抗原 See all Caspase 8 (CASP8) 抗体
    Caspase 8 (CASP8)
    适用
    • 136
    • 70
    • 63
    • 23
    • 16
    • 16
    • 10
    • 1
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    • 1
    宿主
    • 130
    • 24
    • 5
    • 2
    小鼠
    克隆类型
    • 127
    • 33
    单克隆
    标记
    • 96
    • 16
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    • 3
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    • 3
    • 2
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    • 2
    • 2
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    • 2
    • 2
    • 2
    This Caspase 8 antibody is un-conjugated
    应用范围
    • 142
    • 50
    • 44
    • 38
    • 27
    • 26
    • 25
    • 21
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    • 18
    • 8
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    Western Blotting (WB)
    特异性
    This antibody detects proenzyme form of human Caspase-8 by Western blot analysis as well as one of the cleavage products.
    产品特性
    Synonyms: CASP-8, CASP8, MCH5, CAP4, ICE-like apoptotic protease 5, MORT1-associated CED-3homolog, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, Apoptotic cysteineprotease, Apoptotic protease Mch-5
    纯化方法
    Purified
    免疫原
    Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman capase-8 protein and mouse myeloma cells. Genename: CASP8
    克隆位点
    FLICE 1 1-37
    亚型
    IgG
    Top Product
    Discover our top product CASP8 Primary Antibody
  • 应用备注
    Western Blot. Positive Control: MCF-7 cell lysates.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.08 % Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store the antibody at -20 °C. Avoid repeated freezing and thawing.
    Shelf life: One year from despatch.
    有效期
    12 months
  • 抗原
    Caspase 8 (CASP8)
    别名
    Caspase-8 (CASP8 产品)
    别名
    casp8-A antibody, xCaspase-8 antibody, casp8 antibody, CASP8 antibody, CASP-8 antibody, FLICE antibody, MACH antibody, Mch5 antibody, ALPS2B antibody, CAP4 antibody, Casp-8 antibody, MCH5 antibody, caspase-8 antibody, zgc:92075 antibody, caspase 8 L homeolog antibody, death related ced-3/Nedd2-like protein antibody, caspase 8 antibody, caspase-8 antibody, caspase-8-like antibody, caspase 8, apoptosis-related cysteine peptidase antibody, casp8.L antibody, LOC661095 antibody, CASP8 antibody, LOC5563818 antibody, casp8 antibody, LOC100222284 antibody, Casp8 antibody
    背景
    Caspases are key effectors of programmed cell death. They are synthesized as inactive proenzymes which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker which may be involved in the regulation of the different caspases. Caspase-8 is a key enzyme in the apoptosis pathway. Caspase-8 contains two N-terminal region death effector domains which are removed to activate the enzyme along with cleavage into the two subunits. These subunits then for the active protease which is capable of cleaving caspase-3, -6 and -7. These caspases are then capable of cleaving other cellular substrates such as PARP and DFF, which in turn induce apoptosis.Synonyms: Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP-8, CASP8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MCH5, MORT1-associated CED-3 homolog
    基因ID
    841
    UniProt
    Q14790
    途径
    Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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