SHANK1 抗体 (AA 469-691) (PE)
-
- 抗原 See all SHANK1 抗体
- SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))
-
抗原表位
- AA 469-691
-
适用
- 大鼠
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This SHANK1 antibody is conjugated to PE
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Antibody Array (AA)
- 特异性
- Detects ~190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Protein G Purified
- 免疫原
- Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1
- 克隆位点
- N22-21 (Formerly S22-21)
- 亚型
- IgG1
- Top Product
- Discover our top product SHANK1 Primary Antibody
-
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody
SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) unconjugated
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (HRP)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) HRP
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (FITC)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) FITC
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Alkaline Phosphatase (AP))SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Alkaline Phosphatase (AP)
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Biotin)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Biotin
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (APC)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) APC
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (PerCP)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) PerCP
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Atto 488)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Atto 488
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Atto 594)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Atto 594
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Atto 390)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Atto 390
-
- 应用备注
-
- WB (1:1000)
- IHC (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- 说明
-
1 μg/ml of ABIN2483714 was sufficient for detection of Shank1 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Conjugated antibodies should be stored at 4°C
-
- 抗原
- SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))
- 别名
- SHANK1 (SHANK1 产品)
- 别名
- SPANK-1 antibody, SSTRIP antibody, synamon antibody, Shank1a antibody, Spank1 antibody, Sstrip antibody, SH3 and multiple ankyrin repeat domains 1 antibody, SHANK1 antibody, Shank1 antibody
- 背景
- Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).
- 基因ID
- 78957
- NCBI登录号
- NP_113939
- UniProt
- Q9WV48
- 途径
- Synaptic Membrane, Maintenance of Protein Location
-
