MAPK8IP1 抗体 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1)

Details for Product anti-MAPK8IP1 Antibody No. ABIN223343, 供应商: Log in to see
抗原
  • IB1
  • JIP-1
  • Jip1
  • Prkm8ip
  • Skip
  • mjip-2a
  • JIP1
  • Jip-1
  • Mapk8ip
  • PRKM8IP
  • mitogen-activated protein kinase 8 interacting protein 1
  • MAPK8IP1
  • LOC100344706
  • Mapk8ip1
适用
人, 小鼠, 大鼠
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克隆类型
多克隆
标记
This MAPK8IP1 antibody is un-conjugated
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应用范围
Western Blotting (WB)
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选项
Supplier
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Supplier Product No.
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免疫原 Synthetic peptide from mouse JIP1
Blocking Peptide Blocking peptide for this product available: ABIN412803
亚型 IgG
特异性 The antibody recognizes 78 kDa JIP1 in samples from mouse, rat and human origins.
Reactivity to other species has not been tested.
纯化方法 Affinity purified
别名 JIP1 (MAPK8IP1 Antibody 摘要)
背景 JIP1 (JNK-interacting protein-1) is a cytoplasmic protein that possesses an N-terminal JNK-binding domain and a C-terminal SRC homology 3 (SH3) domain. JIP1 selectively bind to JNK, but not to the ERK or p38 MAP kinases. In addition to JNK, JIP1 binds to specific proteins of JNK pathways, including MKK7, MLK3, and DLK, all at separate binding sites. JIP1 has been identified in brain and kidney tissues, whereas JIP2a, JIP2b, and JIP3 are specifically expressed in the brain. Overexpression of JIP1 causes cytoplamic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathways, indicating that JIP1 acts as a cytoplasmic anchor for JNK.
Synonyms: JIP 1 , JNK , IB1 , IB 1 , MAPK8IP 1 , MAPK8IP1 , Mitogen activated protein kinase 8 ,
基因ID 19099
UniProt Q9WVI9
应用备注 Western blotting (0.5-4 μg/mL). However, the optimal concentrations should be determined individually. The antibody recognizes 78 kDa JIP1 in samples from mouse, rat and human origins. In human sample, a ~110 kDa isoform can also be observed. Reactivity to other species has not been tested.
限制 仅限研究用
状态 Liquid
浓度 0.2 mg/mL
缓冲液 100 μg (0.2 mg/mL) protein A purified rabbit anti-JIP1 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5 % BSA, 30 % glycerol, and 0.01 % thimerosal.
储存液 Thimerosal (Merthiolate)
注意事项 This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 The antibody solution should be gently mixed before use.
储存条件 -20 °C
储存方法 For long-term storage, aliquot and freeze at -70 °C.
有效期 12 months
厂商提供的图像
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) antibody (ABIN223343) Western blot analysis of JIP-1 in Jurkat cell lysate (Lane 1) mouse intestine (Lane 2...
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