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VCAM1 抗体

VCAM1 适用: 人 FACS, IP, Func 宿主: 小鼠 Monoclonal 1G11B1 unconjugated
产品编号 ABIN2192131
发货至: 中国
  • 抗原 See all VCAM1 抗体
    VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This VCAM1 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
    过滤
    0.2 μm filtered
    克隆位点
    1G11B1
    Top Product
    Discover our top product VCAM1 Primary Antibody
  • 应用备注
    For immunohistochemistry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive Activated endothelial cells control
    限制
    仅限研究用
  • 缓冲液
    PBS, containing 0.1 % bovine serum albumin
    储存条件
    4 °C
    储存方法
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Wijbrandts, Dijkgraaf, Kraan, Vinkenoog, Smeets, Dinant, Vos, Lems, Wolbink, Sijpkens, Dijkmans, Tak: "The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium." in: Annals of the rheumatic diseases, Vol. 67, Issue 8, pp. 1139-44, (2008) (PubMed).

    Dienst, Grunow, Unruh, Rabausch, Nör, Fries, Gottstein: "Specific occlusion of murine and human tumor vasculature by VCAM-1-targeted recombinant fusion proteins." in: Journal of the National Cancer Institute, Vol. 97, Issue 10, pp. 733-47, (2005) (PubMed).

    Van der Vieren, Crowe, Hoekstra, Vazeux, Hoffman, Grayson, Bochner, Gallatin, Staunton: "The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 4, pp. 1984-90, (1999) (PubMed).

    Thornhill, Wellicome, Mahiouz, Lanchbury, Kyan-Aung, Haskard et al.: "Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 2, pp. 592-8, (1991) (PubMed).

  • 抗原
    VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
    别名
    Vcam-1 CD106 (VCAM1 产品)
    别名
    CD106 antibody, INCAM-100 antibody, Vcam-1 antibody, VCAM1B antibody, fi76d06 antibody, wu:fi76d06 antibody, zgc:158875 antibody, VCAM1 antibody, vascular cell adhesion molecule 1 antibody, vascular cell adhesion molecule 1b antibody, VCAM1 antibody, Vcam1 antibody, vcam1b antibody, VCAM-1 antibody
    背景
    The monoclonal antibody 1G11B1 recognizes vascular cell adhesion molecule-1 (VCAM-1). VCAM-1 is a member of the immunoglobulin superfamily of adhesion molecules, which includes ICAMs, PECAM-s and MADCAM, and is involved in leukocyte-endothelial cell interactions. The immunoglobulin superfamily is a type I transmembrane protein characterized by extracellular immunoglobin domains, a transmembrane region and a cytoplasmic tail. They are essential for the development of the embryo and for immune and inflammatory responses. These transmembrane glycoproteins mediate cell interaction with, and adhesion to, other cells and the extracellular matrix. VCAM-1 contains six immunoglobulin domains of the H-type and interacts with VLA-4 expressed on leukocytes. Multiple adhesion molecules play a role in leukocyte recruitment. The process of migration of a leukocyte through the vascular endothelium consists of the following steps: leukocyte- endothelium interaction (first tethering and rolling and than adhesion) and transendothelial migration. VCAM-1 is almost not expressed under physiological conditions. However, under appropriate pro-inflammatory conditions where the endothelium is exposed to inflammatory cytokines such as tumour necrosis factor-α or IL-1b and becomes activated, VCAM-1 gene expression is rapid elevated by the vascular endothelium. There is also a soluble form of VCAM-1 which is angiogenic and chemotactic for endothelial cells. sVCAM-1 is up- regulated in several disease states (eg, myocardial infarction, type 2 diabetes mellitus, primary antiphospholipid syndrome, and rheumatoid arthritis). Aliases CD106, INCAM-100, L1CAM, MGC99561, DKFZp779G2333, Immunogen Full length protein
    途径
    Carbohydrate Homeostasis
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