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CD46 抗体

CD46 适用: 大鼠 WB, IF, IA 宿主: 小鼠 Monoclonal MM-1 unconjugated
产品编号 ABIN2192126
发货至: 中国
  • 抗原 See all CD46 抗体
    CD46
    适用
    • 118
    • 39
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    • 1
    大鼠
    宿主
    • 85
    • 52
    • 2
    小鼠
    克隆类型
    • 73
    • 66
    单克隆
    标记
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    This CD46 antibody is un-conjugated
    应用范围
    • 91
    • 80
    • 42
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    • 33
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    Western Blotting (WB), Immunofluorescence (IF), Immunoassay (IA)
    过滤
    0.2 μm filtered
    克隆位点
    MM-1
    Top Product
    Discover our top product CD46 Primary Antibody
  • 应用备注
    For immunohistology, immunofluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive Western blotting: rat testis lysate, non-reducing conditions, band size 38 kDa (Ref. 1and 4) control
    限制
    仅限研究用
  • 缓冲液
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    有效期
    12 months
  • Mizuno, Harris, Morgan: "Spermatogenic cells distal to the blood-testis barrier in rats lack C3 convertase regulators and may be at risk of complement-mediated injury." in: Journal of reproductive immunology, Vol. 69, Issue 1, pp. 23-34, (2006) (PubMed).

    Mizuno, Donev, Harris, Morgan: "CD55 in rat male reproductive tissue: differential expression in testis and expression of a unique truncated isoform on spermatozoa." in: Molecular immunology, Vol. 44, Issue 7, pp. 1613-22, (2006) (PubMed).

    Mizuno, Harris, Suzuki, Matsuo, Morgan: "Expression of CD46 in developing rat spermatozoa: ultrastructural localization and utility as a marker of the various stages of the seminiferous tubuli." in: Biology of reproduction, Vol. 72, Issue 4, pp. 908-15, (2005) (PubMed).

    Mizuno, Harris, Johnson, Morgan: "Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3." in: Biology of reproduction, Vol. 71, Issue 4, pp. 1374-83, (2004) (PubMed).

  • 抗原
    CD46
    别名
    CD46 (CD46 产品)
    别名
    AHUS2 antibody, MCP antibody, MIC10 antibody, TLX antibody, TRA2.10 antibody, Mcp antibody, CD46 antibody, CD46 molecule antibody, CD46 antigen, complement regulatory protein antibody, CD46 molecule, complement regulatory protein antibody, membrane cofactor protein-like antibody, CD46 antibody, Cd46 antibody, LOC100341359 antibody, LOC103789310 antibody
    背景
    The monoclonal antibody MM.1 recognizes CD46, also known as membrane cofactor protein. An immunohistological survey of rat tissues revealed that CD46 is expressed only in the testis and epididymis of adult rats more specifically, only by spermatozoa and late spermatozoal precursors. In contrast, in humans, CD46 is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It functions as a cofactor by binding to C3b and C4b. Binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. In human, it also serves as a receptor for measles virus. Two isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). Aliases Membrane cofactor protein Immunogen Second and third SCR domains of MCP fused to IgG-Fc, MCP23-Ig
    途径
    Regulation of Actin Filament Polymerization
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