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IL1RN 抗体

IL1RN 适用: 人 WB, IHC (fro), IA 宿主: 小鼠 Monoclonal 2D11 unconjugated
产品编号 ABIN2191920
发货至: 中国
  • 抗原 See all IL1RN 抗体
    IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
    适用
    • 77
    • 34
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    • 9
    • 9
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    宿主
    • 96
    • 32
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    • 1
    • 1
    小鼠
    克隆类型
    • 103
    • 35
    单克隆
    标记
    • 68
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    This IL1RN antibody is un-conjugated
    应用范围
    • 114
    • 52
    • 37
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    • 13
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    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)
    过滤
    0.2 μm filtered
    克隆位点
    2D11
    Top Product
    Discover our top product IL1RN Primary Antibody
  • 应用备注
    For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
    限制
    仅限研究用
  • 缓冲液
    PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    有效期
    12 months
  • Muzio, Polentarutti, Facchetti, Peri, Doni, Sironi, Transidico, Salmona, Introna, Mantovani: "Characterization of type II intracellular IL-1 receptor antagonist (IL-1ra3): a depot IL-1ra." in: European journal of immunology, Vol. 29, Issue 3, pp. 781-8, (1999) (PubMed).

    Muzio, Polentarutti, Sironi, Poli, De Gioia, Introna, Mantovani, Colotta: "Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist." in: The Journal of experimental medicine, Vol. 182, Issue 2, pp. 623-8, (1995) (PubMed).

  • 抗原
    IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
    别名
    Il-1ra3 (IL1RN 产品)
    别名
    DIRA antibody, ICIL-1RA antibody, IL-1RN antibody, IL-1ra antibody, IL-1ra3 antibody, IL1F3 antibody, IL1RA antibody, IRAP antibody, MVCD4 antibody, IRAP1 antibody, IL1RN antibody, IL-1RA antibody, F630041P17Rik antibody, interleukin 1 receptor antagonist antibody, interleukin 1 receptor antagonist-like antibody, IL1RN antibody, Il1rn antibody, IL1RNL antibody
    背景
    The antibody reacts specificly with Human IL-1ra3. IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1 ra type II (IL-1ra3), have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is to limit the pro- inflammatory action of cell debris. Studies have shown that IL-1ra3 is expressed by various cell types upon exposure to inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes.
    途径
    NF-kappaB Signaling, Hormone Transport, Cancer Immune Checkpoints
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