(1 reference)-
- 抗原 See all TREM2 抗体
- TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This TREM2 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunoassay (IA)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 6E9
- Top Product
- Discover our top product TREM2 Primary Antibody
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anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) antibody
TREM2 适用: 小鼠, 人, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-100) antibodyTREM2 适用: 小鼠, 人, 大鼠, Pig WB, ELISA, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-228) antibodyTREM2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 1-227) antibodyTREM2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (Internal Region) antibodyVerified TREM2 适用: 小鼠 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 22-48), (N-Term) antibodyTREM2 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB38661 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 42-56), (Extracellular), (N-Term) antibodyTREM2 适用: 小鼠, 人, 大鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-174) antibodyTREM2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 19-161) antibodyTREM2 适用: 人 WB, ELISA, FACS, ICC, IF 宿主: 小鼠 Monoclonal 2B5 unconjugated
anti-Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) (AA 42-56), (Extracellular), (N-Term) antibody (PE)TREM2 适用: 小鼠, 人, 大鼠 FACS, LCI 宿主: 兔 Polyclonal PE
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- 应用备注
- For flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis." in: Nature, Vol. 428, Issue 6984, pp. 758-63, (2004) (PubMed).
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: "Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis." in: Nature, Vol. 428, Issue 6984, pp. 758-63, (2004) (PubMed).
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- 抗原
- TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))
- 别名
- Triggering Receptor Expressed On Myeloid Cells 2 (TREM2 产品)
- 别名
- TREM-A1 antibody, TREM-B1 antibody, TREM2 antibody, trem-2 antibody, trem2a antibody, trem2b antibody, trem2c antibody, TREM-2 antibody, Trem2a antibody, Trem2b antibody, Trem2c antibody, triggering receptor expressed on myeloid cells 2 antibody, trem-like transcript 2 protein antibody, TREM2 antibody, trem2 antibody, LOC100228399 antibody, Trem2 antibody
- 背景
- The monoclonal antibody 6E9 recognizes mouse membrane-bound as well as soluble triggering receptor expressed on myeloid cells-2 (TREM-2). TREM-2 is a 26 kDa transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia. Defects in TREM-2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). TREM-2, like TREM-1, can be cleaved on the membrane to release a soluble form of TREM-2 (sTREM-2). Elevated levels of sTREM-2 in CSF of multiple sclerosis patients have been detected. This elevated level may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies. Aliases Triggering receptor expressed on monocytes 2, TREM2 Immunogen Mouse recombinant TREM-2 protein
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