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IRS1 抗体 (pSer636)

IRS1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN196979
发货至: 中国
  • 抗原 See all IRS1 抗体
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    抗原表位
    • 31
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    pSer636
    适用
    • 292
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    • 209
    • 23
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    • 16
    • 16
    • 15
    • 2
    • 1
    • 1
    人, 小鼠
    宿主
    • 292
    • 12
    克隆类型
    • 285
    • 19
    多克隆
    标记
    • 138
    • 14
    • 12
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    This IRS1 antibody is un-conjugated
    应用范围
    • 172
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    • 93
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    • 67
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    • 7
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    IRS-1 antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 636.
    纯化方法
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    免疫原
    The antiserum was produced against synthesized phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 636 (P-M-SP-P-K).
    Top Product
    Discover our top product IRS1 Primary Antibody
  • 应用备注
    Western Blot: 1: 500approx. 1: 1000. Immunohistochemistry: 1: 50-1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0mg/mL
    缓冲液
    PBS(without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
  • 抗原
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    别名
    IRS1 (IRS1 产品)
    别名
    HIRS-1 antibody, G972R antibody, IRS-1 antibody, IRS1IRM antibody, irs1 antibody, irsu antibody, IRS1 antibody, irs-1 antibody, irs1-a antibody, insulin receptor substrate 1 antibody, insulin receptor substrate 2 antibody, insulin receptor substrate 1 S homeolog antibody, IRS1 antibody, Irs1 antibody, irs2 antibody, irs1.S antibody
    背景
    Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.Synonyms: IRS-1, Insulin receptor substrate 1
    基因ID
    3667
    NCBI登录号
    NP_005535
    UniProt
    P35568
    途径
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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