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HDAC5 抗体 (pSer498)

HDAC5 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN196932
发货至: 中国
  • 抗原 See all HDAC5 抗体
    HDAC5 (Histone Deacetylase 5 (HDAC5))
    抗原表位
    • 23
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer498
    适用
    • 79
    • 58
    • 43
    • 33
    • 28
    • 18
    • 12
    • 2
    • 2
    • 2
    • 1
    人, 小鼠
    宿主
    • 77
    • 2
    克隆类型
    • 77
    • 2
    多克隆
    标记
    • 49
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This HDAC5 antibody is un-conjugated
    应用范围
    • 70
    • 25
    • 24
    • 22
    • 22
    • 18
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site. HDAC5 (phospho-Ser498) antibody detects endogenous levels of HDAC5 only when phosphorylated at serine 498.
    纯化方法
    Immunoaffinity chromatography using epitope-specific phosphopeptide.
    免疫原
    The antiserum was produced against synthesized phosphopeptide derived from human HDAC5 around the phosphorylation site of serine 498 (T-Q-Sp-S-P).
    Top Product
    Discover our top product HDAC5 Primary Antibody
  • 应用备注
    Suitable for use in Suitable for use in Western blot (1: 500-1: 1000) andImmunohistochemistry on paraffin-embedded sections (1: 50-1: 100).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody (in aliquots) at -20 °C.
  • 抗原
    HDAC5 (Histone Deacetylase 5 (HDAC5))
    别名
    HDAC5 (HDAC5 产品)
    背景
    HDAC5 is a member of the class II mammalian histone deacetylase family, which is structurally related to yeast HDA1. Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence.Both domains are required for HDAC5-mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.Synonyms: Antigen NY-CO-9, HD5, Histone deacetylase 5, KIAA0600
    基因ID
    10014
    NCBI登录号
    NP_001015053
    UniProt
    Q9UQL6
    途径
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Monocarboxylic Acid Catabolic Process
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