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MAP2K3 抗体 (pSer189)

MAP2K3 适用: 人, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN196863
发货至: 中国
  • 抗原 See all MAP2K3 抗体
    MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
    抗原表位
    • 25
    • 19
    • 15
    • 15
    • 9
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    • 1
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    • 1
    • 1
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    pSer189
    适用
    • 141
    • 101
    • 81
    • 11
    • 10
    • 5
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    人, 大鼠
    宿主
    • 144
    • 12
    克隆类型
    • 130
    • 26
    多克隆
    标记
    • 72
    • 9
    • 8
    • 6
    • 6
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    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
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    • 2
    This MAP2K3 antibody is un-conjugated
    应用范围
    • 122
    • 49
    • 40
    • 39
    • 33
    • 28
    • 22
    • 9
    • 9
    • 8
    • 8
    • 2
    • 1
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    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    MKK3 (phospho-Ser189) antibody detects endogenous levels of MKK3 only when phosphorylated at serine189.
    纯化方法
    Immunoaffinity chromatography.
    免疫原
    Synthetic phosphopeptide derived from human MKK3 around the phosphorylation site of serine 189 (V-D-SP-V-A).
    Top Product
    Discover our top product MAP2K3 Primary Antibody
  • 应用备注
    Suitable for use in Western blot (1: 500approx. 1: 1000) and Immunohistochemistry (1: 50approx. 1: 100).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody (in aliquots) at -20 °C.
  • 抗原
    MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
    别名
    MAP2K3 (MAP2K3 产品)
    别名
    MAPKK3 antibody, MEK3 antibody, MKK3 antibody, PRKMK3 antibody, SAPKK-2 antibody, SAPKK2 antibody, AW212142 antibody, Prkmk3 antibody, mMKK3b antibody, Mkk3 antibody, mitogen-activated protein kinase kinase 3 antibody, mitogen activated protein kinase kinase 3 antibody, MAP kinase activator XMEK3 antibody, MAP2K3 antibody, Map2k3 antibody, map2k3 antibody
    背景
    MEK3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.Synonyms: Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MEK3, MKK3
    基因ID
    5606
    NCBI登录号
    NP_002747
    UniProt
    P46734
    途径
    MAPK Pathway, TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2
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