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RPS6KA6 抗体 (N-Term)

RPS6KA6 适用: 人, 猴 WB, IHC (p) 宿主: 兔 Polyclonal RB0894 unconjugated
产品编号 ABIN1882127
发货至: 中国
  • 抗原 See all RPS6KA6 抗体
    RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))
    抗原表位
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    AA 15-45, N-Term
    适用
    • 25
    • 2
    • 2
    人, 猴
    宿主
    • 18
    • 7
    • 1
    克隆类型
    • 19
    • 7
    多克隆
    标记
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RPS6KA6 antibody is un-conjugated
    应用范围
    • 15
    • 12
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This RSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human RSK4.
    克隆位点
    RB0894
    亚型
    Ig Fraction
    Top Product
    Discover our top product RPS6KA6 Primary Antibody
  • 应用备注
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Sulzmaier, Young-Robbins, Jiang, Geerts, Prechtl, Matter, Kesari, Ramos: "RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics." in: Oncotarget, Vol. 7, Issue 48, pp. 79869-79884, (2018) (PubMed).

    Thakur, Sun, Bollig, Wu, Biliran, Banerjee, Sarkar, Liao: "Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 14, pp. 4427-36, (2008) (PubMed).

    Yntema, van den Helm, Kissing, van Duijnhoven, Poppelaars, Chelly, Moraine, Fryns, Hamel, Heilbronner, Pander, Brunner, Ropers, Cremers, van Bokhoven: "A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation." in: Genomics, Vol. 62, Issue 3, pp. 332-43, (2000) (PubMed).

  • 抗原
    RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))
    别名
    RSK4 (RPS6KA6 产品)
    别名
    PP90RSK4 antibody, RSK4 antibody, 2610524K04Rik antibody, RGD1560817 antibody, ribosomal protein S6 kinase A6 antibody, ribosomal protein S6 kinase polypeptide 6 antibody, RPS6KA6 antibody, Rps6ka6 antibody
    背景
    Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK). The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).
    分子量
    83872
    NCBI登录号
    NP_055311
    UniProt
    Q9UK32
    途径
    MAPK Pathway
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