(5 references)-
- 抗原 See all TICAM1 抗体
- TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
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抗原表位
- AA 115-143, N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TICAM1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This TICAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the N-terminal region of human TICAM1.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product TICAM1 Primary Antibody
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anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 443-685) antibody
TICAM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 663-712) antibodyTICAM1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 263-526) antibodyTICAM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibodyTICAM1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibodyTICAM1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 20-200) antibodyTICAM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (C-Term) antibodyTICAM1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (C-Term) antibodyTICAM1 适用: 人 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibodyVerified TICAM1 适用: 人 IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 120-420) antibodyTICAM1 适用: 人, 猴 WB 宿主: 小鼠 Monoclonal 1G7 unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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: "Natural selection in the TLR-related genes in the course of primate evolution." in: Immunogenetics, Vol. 60, Issue 12, pp. 727-35, (2008) (PubMed).
: "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling." in: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 24526-32, (2003) (PubMed).
: "TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction." in: Nature immunology, Vol. 4, Issue 2, pp. 161-7, (2003) (PubMed).
: "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways." in: Oncogene, Vol. 22, Issue 21, pp. 3307-18, (2003) (PubMed).
: "Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 12, pp. 6668-72, (2002) (PubMed).
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: "Natural selection in the TLR-related genes in the course of primate evolution." in: Immunogenetics, Vol. 60, Issue 12, pp. 727-35, (2008) (PubMed).
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- 抗原
- TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
- 别名
- TICAM1 (TICAM1 产品)
- 别名
- IIAE6 antibody, MyD88-3 antibody, PRVTIRB antibody, TICAM-1 antibody, TRIF antibody, AW046014 antibody, AW547018 antibody, trif antibody, toll like receptor adaptor molecule 1 antibody, toll-like receptor adaptor molecule 1 antibody, TICAM1 antibody, Ticam1 antibody, ticam1 antibody
- 背景
- Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
- 分子量
- 76422
- NCBI登录号
- NP_891549
- UniProt
- Q8IUC6
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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