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STAT1 抗体 (C-Term)

STAT1 适用: 人 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB41406 unconjugated
产品编号 ABIN1881847
发货至: 中国
  • 抗原 See all STAT1 抗体
    STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
    抗原表位
    • 51
    • 38
    • 15
    • 15
    • 12
    • 7
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    • 3
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    AA 717-745, C-Term
    适用
    • 190
    • 103
    • 75
    • 18
    • 18
    • 16
    • 15
    • 13
    • 11
    • 7
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    • 4
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    宿主
    • 187
    • 21
    • 2
    克隆类型
    • 164
    • 46
    多克隆
    标记
    • 117
    • 11
    • 11
    • 8
    • 6
    • 6
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    • 5
    • 5
    • 5
    • 3
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    This STAT1 antibody is un-conjugated
    应用范围
    • 141
    • 67
    • 52
    • 47
    • 38
    • 31
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    • 8
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    • 4
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This STAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 717-745 amino acids from the C-terminal region of human STAT1.
    克隆位点
    RB41406
    亚型
    Ig Fraction
    Top Product
    Discover our top product STAT1 Primary Antibody
  • 应用备注
    IF: 1:25. WB: 1:1000. IHC-P-Leica: 1:1000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500. FC: 1:25
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Yang, Shen, Xu, Yang, Tsai, Keng, Chen, Lee: "Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition." in: Scientific reports, Vol. 7, Issue 1, pp. 7958, (2017) (PubMed).

    Clarke, Clifford, Jindarat, Proud, Pang, Belvisi, Knox: "TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein." in: The Journal of biological chemistry, Vol. 285, Issue 38, pp. 29101-10, (2010) (PubMed).

    Sakamoto, Qin, Navarro, Gamero, Potla, Yi, Zhu, Baker, Feldman, Larner: "Cells previously desensitized to type 1 interferons display different mechanisms of activation of stat-dependent gene expression from naïve cells." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3245-53, (2004) (PubMed).

    Zhang, Cho, Petersen, Zhu, Dong: "Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1." in: Carcinogenesis, Vol. 25, Issue 7, pp. 1165-75, (2004) (PubMed).

  • 抗原
    STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
    别名
    STAT1 (STAT1 产品)
    别名
    CANDF7 antibody, ISGF-3 antibody, STAT91 antibody, 2010005J02Rik antibody, AA408197 antibody, XStat1 antibody, STAT4 antibody, DD6G4-4 antibody, STAT antibody, STAT1 antibody, dZ182H3.3 antibody, si:by134g18.2 antibody, si:by51f19.1 antibody, si:dz182h3.3 antibody, si:dz199m19.1 antibody, si:dz73o4.2 antibody, stat1 antibody, signal transducer and activator of transcription 1 antibody, signal transducer and activator of transcription 1 L homeolog antibody, signal transducer and activator of transcription 1, 91kDa antibody, signal transducer and activator of transcription 4 antibody, signal transducer and activator of transcription 1a antibody, STAT1 antibody, Stat1 antibody, stat1.L antibody, stat4 antibody, stat1a antibody
    背景
    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq].
    分子量
    87335
    NCBI登录号
    NP_009330, NP_644671
    UniProt
    P42224
    途径
    JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
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