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Frataxin 抗体 (N-Term)

FXN 适用: 人 WB 宿主: 兔 Polyclonal RB41914 unconjugated
产品编号 ABIN1881356
发货至: 中国
  • 抗原 See all Frataxin (FXN) 抗体
    Frataxin (FXN)
    抗原表位
    • 13
    • 10
    • 9
    • 7
    • 6
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 36-64, N-Term
    适用
    • 68
    • 22
    • 13
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 62
    • 13
    克隆类型
    • 64
    • 11
    多克隆
    标记
    • 39
    • 7
    • 7
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Frataxin antibody is un-conjugated
    应用范围
    • 58
    • 44
    • 26
    • 10
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This FXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human FXN.
    克隆位点
    RB41914
    亚型
    Ig Fraction
    Top Product
    Discover our top product FXN Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Tsai, Barondeau: "Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex." in: Biochemistry, Vol. 49, Issue 43, pp. 9132-9, (2010) (PubMed).

    Thierbach, Drewes, Fusser, Voigt, Kuhlow, Blume, Schulz, Reiche, Glatt, Epe, Steinberg, Ristow: "The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals." in: The Biochemical journal, Vol. 432, Issue 1, pp. 165-72, (2010) (PubMed).

    Mariño, Zaldivar, Mesa, Mederos, Rodríguez, Gotay, Labrada, Ochoa, Macleod, Pérez: "Low predisposition to instability of the Friedreich ataxia gene in Cuban population." in: Clinical genetics, Vol. 77, Issue 6, pp. 598-600, (2010) (PubMed).

    Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

  • 抗原
    Frataxin (FXN)
    别名
    FXN (FXN 产品)
    背景
    This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.
    分子量
    23135
    NCBI登录号
    NP_000135, NP_001155178, NP_852090
    UniProt
    Q16595
    途径
    Transition Metal Ion Homeostasis, Regulation of Cell Size
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