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Cyclin D1 抗体 (C-Term)

Name: Cyclin D1 抗体 (C-Term)
SKU: ABIN1881175
Availability: OutOfStock

CCND1 适用: 人 WB 宿主: 兔 Polyclonal RB42158 unconjugated

CCND1 Antibody (ABIN1881175 and ABIN2838924) western blot analysis in Hela cell line lysates (35 μg/lane).

1 image

(6 references)

产品编号 ABIN1881175

发货至: 中国

Datasheet as PDF

抗原 See all Cyclin D1 (CCND1) 抗体

Cyclin D1 (CCND1)
抗原表位
22

20

16

16

13

10

9

7

7

7

7

7

6

6

5

5

3

3

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 267-294, C-Term
适用
235

128

123

38

19

19

17

10

9

8

4

3

3

3

3

2

1

1

1

1

1
人
宿主
203

56

1
兔
Compatible Secondaries
克隆类型
192

66
多克隆
标记
116

28

21

9

7

7

7

7

7

7

7

4

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1
This Cyclin D1 antibody is un-conjugated
应用范围
196

89

66

64

42

31

27

27

25

22

19

13

6

5

3

2

2

2

1

1
Western Blotting (WB)

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-294 amino acids from the C-terminal region of human CCND1.

克隆位点

RB42158

亚型

Ig Fraction

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anti-Cyclin D1 (CCND1) (C-Term) antibody
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anti-Cyclin D1 (CCND1) antibody
KO Validated CCND1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-Cyclin D1 (CCND1) (AA 167-295) antibody
CCND1 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3B6G3 unconjugated

anti-Cyclin D1 (CCND1) (AA 1-295) antibody
CCND1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1F7F5 unconjugated

anti-Cyclin D1 (CCND1) (C-Term) antibody
CCND1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin D1 (CCND1) (AA 68-97) antibody
CCND1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB8066 unconjugated

anti-Cyclin D1 (CCND1) (AA 68-97) antibody
CCND1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin D1 (CCND1) antibody
CCND1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, FACS, IF, StM 宿主: 小鼠 Monoclonal DCS-6 unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Yang, Wei, Wang, Shen, Xu, Cao: "TRAF4 enhances oral squamous cell carcinoma cell growth, invasion and migration by Wnt-β-catenin signaling pathway." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 11837-46, (2016) (PubMed).

Aggarwal, Vaites, Kim, Mellert, Gurung, Nakagawa, Herlyn, Hua, Rustgi, McMahon, Diehl: "Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase." in: Cancer cell, Vol. 18, Issue 4, pp. 329-40, (2010) (PubMed).

Halilovic, She, Ye, Pagliarini, Sellers, Solit, Rosen: "PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling." in: Cancer research, Vol. 70, Issue 17, pp. 6804-14, (2010) (PubMed).

Zheng, Armes, Slavin, Zhu, Ni: "Preliminary comparison of tumor biologic factors in breast carcinomas from Australian and Chinese women." in: Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology, Vol. 32, Issue 3, pp. 155-60, (2010) (PubMed).

Satiroglu-Tufan, Dodurga, Gok, Cetinkaya, Feitelson: "RNA interference-mediated URG4 gene silencing diminishes cyclin D1 mRNA expression in HepG2 cells." in: Genetics and molecular research : GMR, Vol. 9, Issue 3, pp. 1557-67, (2010) (PubMed).

Iwatani, Fujimoto, Ito: "Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3-p300 interaction." in: Biochemical and biophysical research communications, Vol. 400, Issue 3, pp. 426-31, (2010) (PubMed).
抗原

Cyclin D1 (CCND1)

别名

CCND1 (CCND1 产品)

别名

BCL1 antibody, D11S287E antibody, PRAD1 antibody, U21B31 antibody, AI327039 antibody, CycD1 antibody, Cyl-1 antibody, bcl-1 antibody, cD1 antibody, cb161 antibody, cycd1 antibody, etID37810.7 antibody, fb52e01 antibody, fc45c08 antibody, fc83a12 antibody, id:ibd1198 antibody, wu:fb52e01 antibody, wu:fc45c08 antibody, wu:fc83a12 antibody, ccnd1b antibody, prad1 antibody, ccnd1 antibody, ccnd1a antibody, bcl1 antibody, d11s287e antibody, u21b31 antibody, CCND1 antibody, cyclin D1 antibody, cyclin D1 S homeolog antibody, cyclin D1 L homeolog antibody, CCND1 antibody, Ccnd1 antibody, ccnd1 antibody, ccnd1.S antibody, ccnd1.L antibody

背景

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

分子量

33729

NCBI登录号

NP_444284

UniProt

P24385

途径

PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling