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NONO 抗体 (C-Term)

NONO 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠, 兔 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN184024
发货至: 中国
  • 抗原 See all NONO 抗体
    NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
    抗原表位
    • 15
    • 12
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    C-Term
    适用
    • 76
    • 36
    • 32
    • 15
    • 10
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 1
    人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠, 兔
    宿主
    • 70
    • 5
    • 2
    克隆类型
    • 62
    • 15
    多克隆
    标记
    • 37
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This NONO antibody is un-conjugated
    应用范围
    • 59
    • 35
    • 27
    • 17
    • 14
    • 14
    • 14
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    序列
    DGTLGLTPPT TERFGQAATM EGIGAIGGTP PAFNRAAPGA EFAPNKRRRY
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%
    产品特性
    This is a rabbit polyclonal antibody against NONO. It was validated on Western Blot and immunohistochemistry.
    纯化方法
    Protein A purified
    免疫原
    The immunogen is a synthetic peptide directed towards the C terminal region of human NONO
    Top Product
    Discover our top product NONO Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 471 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

  • 抗原
    NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
    别名
    NONO (NONO 产品)
    别名
    NMT55 antibody, NRB54 antibody, P54 antibody, P54NRB antibody, nmt55 antibody, nrb54 antibody, p54nrb antibody, xp54nrb antibody, AA407051 antibody, AV149256 antibody, nonA antibody, non-POU domain containing octamer binding antibody, non-POU domain containing, octamer-binding antibody, non-POU domain containing, octamer binding L homeolog antibody, non-POU-domain-containing, octamer binding protein antibody, NONO antibody, Nono antibody, nono.L antibody
    背景
    NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
    Alias Symbols: P54, NMT55, NRB54, P54NRB
    Protein Interaction Partner: SFPQ, PTBP1, PRKAA2, PIN1, NONO, FUS, DDX6, C11orf68, PSPC1, HUWE1, LMO4, UBC, SUMO2, STAU1, MDM2, RPA3, RPA2, RPA1, ASB18, WWOX, ASB3, ERG, EED, rev, WBP4, TCERG1, APBB1, PRPF40A, LMNA, CD81, PAN2, CTNNB1, ORC5, MYC, ITGA4, IL7R, FN1, EWSR1, YLPM1, RNF43
    Protein Size: 471
    分子量
    52 kDa
    基因ID
    4841
    NCBI登录号
    NM_007363, NP_031389
    UniProt
    Q15233
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