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- 抗原 See all CLEC7A 抗体
- CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This CLEC7A antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- This antibody recognises beta-glucan receptor, also known as Dectin-1. This antibody inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The Low Endotoxin version (SM2025LE) is recommended for functional studies.
- 纯化方法
- Affinity Chromatography on Protein G
- 免疫原
- Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1. Spleen cells from immunised Fischer rats were fused with cells of the rat Y3 myeloma cell line.
- 克隆位点
- 2A11
- 亚型
- IgG2b
- Top Product
- Discover our top product CLEC7A Primary Antibody
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anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 66-247) antibody
CLEC7A 适用: 人 FACS, WB, ELISA, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 4G2G6 unconjugated
anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 41-140) antibodyCLEC7A 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 1-44) antibodyCLEC7A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) antibodyCLEC7A 适用: 人 FACS, IHC (fro) 宿主: 小鼠 Monoclonal 15E2 unconjugated
anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) antibody (APC)CLEC7A 适用: 人 FACS 宿主: 小鼠 Monoclonal 15E2 APC
anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) antibody (PE)CLEC7A 适用: 人 FACS 宿主: 小鼠 Monoclonal 15E2 PE
anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 36-127) antibodyCLEC7A 适用: 人, 猴 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 70-98), (N-Term) antibodyCLEC7A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB30231 unconjugated
anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) (Middle Region) antibodyCLEC7A 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA. Immunohistochemistry on frozen sections: The epitope recognised by 2A11 is sensitive to H202 treatment, therefore quenching with 0.3 % H202 should be performed after incubation with the primary antibody. Flow Cytometry: 1/10 - 1/50, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS, pH 7.4 containing 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))
- 别名
- CLEC7A / Dectin-1 (CLEC7A 产品)
- 别名
- CLEC7A antibody, BGR antibody, Clecsf12 antibody, beta-GR antibody, CANDF4 antibody, CLECSF12 antibody, DECTIN1 antibody, Clec7b antibody, RGD1565140 antibody, C-type lectin domain containing 7A antibody, C-type lectin domain family 7, member a antibody, CLEC7A antibody, Clec7a antibody
- 背景
- Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells. As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk.Synonyms: BGR, Beta-glucan receptor, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, CLECSF12, DC-associated C-type lectin 1, DECTIN1, Dendritic cell-associated C-type lectin 1
- 基因ID
- 56644
- NCBI登录号
- NP_064392
- UniProt
- Q6QLQ4
- 途径
- Activation of Innate immune Response
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