CLEC7A 抗体 (C-Type Lectin Domain Family 7, Member A) (Biotin)

Details for Product anti-CLEC7A Antibody No. ABIN181893, 供应商: Log in to see
抗原
  • CLEC7A
  • BGR
  • Clecsf12
  • beta-GR
  • CANDF4
  • CLECSF12
  • DECTIN1
  • Clec7b
  • RGD1565140
  • C-type lectin domain family 7, member A
  • C-type lectin domain family 7, member a
  • dendritic cell-associated C-type lectin 1
  • CLEC7A
  • Clec7a
  • LOC100339146
适用
小鼠
154
125
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2
宿主
大鼠
96
88
63
2
克隆类型 (克隆位点)
单克隆 ()
标记
This CLEC7A antibody is conjugated to Biotin
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22
12
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4
2
2
2
2
2
2
1
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1
1
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS)
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61
26
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13
8
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5
1
1
选项
Supplier
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Supplier Product No.
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免疫原 Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1. Spleen cells from immunised Fischer rats were fused with cells of the rat Y3 myeloma cell line.
克隆位点 2A11
亚型 IgG2b
特异性 This antibody recognises beta-glucan receptor, also known as Dectin-1. This antibody inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The low endotoxin version (SM2025LE) is recommended for functional studies.
纯化方法 Affinity chromatography on Protein G
别名 CLEC7A / Dectin-1 (CLEC7A Antibody 摘要)
背景 Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells. As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk.Synonyms: BGR, Beta-glucan receptor, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, CLECSF12, DC-associated C-type lectin 1, DECTIN1, Dendritic cell-associated C-type lectin 1
基因ID 56644
NCBI登录号 NP_064392
UniProt Q6QLQ4
途径 Activation of Innate immune Response
应用备注 Flow Cytometry: Neat - 1/10, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
浓度 0.1 mg/mL
缓冲液 PBS, pH 7.4 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
厂商提供的图像
Flow Cytometry (FACS) image for anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) antibody (Biotin) (ABIN181893) Staining of mouse peripheral blood granulocytes with RAT ANTI MSE BETA GLUCAN RECEPTO...
背景 Underhill, Rossnagle, Lowell, Simmons: "Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production." in: Blood, Vol. 106, Issue 7, pp. 2543-50, 2005 (PubMed).

Taylor, Brown, Reid, Willment, Martinez-Pomares, Gordon, Wong: "The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 7, pp. 3876-82, 2002 (PubMed).

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