小鼠 anti-人 IgA (Heavy Chain) Antibody

ABIN180873 产品详细信息, 供应商: Log in to see
抗原
抗原表位
Heavy Chain
200
157
127
48
39
19
16
16
16
6
6
3
3
3
2
2
2
1
1
1
1
适用

778
195
122
76
48
48
38
36
36
35
27
23
14
14
7
5
4
3
3
3
2
1
1
1
宿主
小鼠
755
329
279
42
37
12
9
克隆类型 (克隆位点)
单克隆 ()
应用范围
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
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Supplier
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免疫原 Reduced and alkylated Human IgA. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1myeloma cell line. Genename: IgA
克隆位点 Mc24-2E11
亚型 IgG1
纯化方法 Affinity Chromatography on Protein G.
背景 Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.Synonyms: Human Immunoglobulin A
分子量 160 kDa
研究领域 Immunology, Secondary Antibodies
应用备注 ELISA. Western Blot. Immunoprecipitation. Immunohistochemistry on Frozen Sections.

Other applications not tested.
Otimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
浓度 1.0 mg/mL
缓冲液 PBS, pH 7.4, 0.09 % Sodium Azide
储存液 Sodium azide
注意事项 WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -28 °C for longer.
背景 Creasey, Staalsoe, Raza, Arnot, Rowe: "Nonspecific immunoglobulin M binding and chondroitin sulfate A binding are linked phenotypes of Plasmodium falciparum isolates implicated in malaria during pregnancy." in: Infection and immunity, Vol. 71, Issue 8, pp. 4767-71, 2003 (PubMed).