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CDKN1A 抗体 (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1)) (AA 1-80)

Details for Product anti-CDKN1A Antibody No. ABIN180466, 供应商: Log in to see
抗原
  • p21
  • cip1
  • p16Xic2
  • CCND1
  • sdi1
  • waf1
  • cap20
  • cdkn1
  • mda-6
  • p21cip1
  • CDKN1A
  • si:ch1073-48m5.2
  • Cip1
  • UV96
  • Waf1
  • CAP20
  • CDKN1
  • CIP1
  • MDA-6
  • P21
  • SDI1
  • WAF1
  • p21CIP1
  • CDKI
  • Cdkn1
  • mda6
  • p21Cip1
  • p21WAF
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1)
  • cyclin-dependent kinase inhibitor 1
  • cyclin-dependent kinase inhibitor 1A
  • cyclin-dependent kinase inhibitor 1A (P21)
  • cdkn1a
  • cki1
  • CDKN1A
  • LOC100348489
  • Cdkn1a
Alternatives
anti-大鼠 CDKN1A 抗体 for Cytometry by Time of Flight
抗原表位
AA 1-80, N-Term
50
39
27
20
18
18
18
18
15
15
15
15
14
13
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12
9
8
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5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
适用
人, 大鼠
535
186
126
30
23
10
6
5
4
2
1
1
1
1
1
1
1
1
宿主
小鼠
310
267
2
1
克隆类型 (克隆位点)
单克隆 ()
标记
This CDKN1A antibody is un-conjugated
30
29
29
22
15
15
13
13
9
9
7
7
7
7
7
7
7
7
7
6
6
6
6
4
4
4
4
4
4
应用范围
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
330
212
172
167
136
101
67
62
53
33
30
13
7
6
6
2
1
1
Supplier
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免疫原 Full length human recombinant p21 protein. Remarks: Mol. Wt. of antigen: 21 kDaEpitope: aa 1-80
克隆位点 CP74
亚型 IgG2b
特异性 This antibody detects p21/WAF1.
Cellular Localization: Nuclear.
产品特性 Synonyms: CAP20, CDKN1, CIP1, MDA6, MDA-6, PIC1, SDI1, WAF1, Cyclin-dependent kinase inhibitor 1,CDK-interacting protein 1, Melanoma differentiation-associated protein 6
纯化方法 Protein A Chromatography.
别名 CDKN1A / p21WAF1 (CDKN1A Antibody 摘要)
背景 P21WAF1/Cip1/Sdi1/Pic1 is a tumor suppressor protein. Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. It also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process.Synonyms: CAP20, CDK-interacting protein 1, CDKN1, CIP1, Cyclin-dependent kinase inhibitor 1, MDA-6, MDA6, Melanoma differentiation-associated protein 6, PIC1, SDI1, WAF1
基因ID 1026
UniProt P38936
途径 p53 Pathway, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy
应用备注 Flow Cytometry. Immunoprecipitation (Native verified): Use Protein A, 2 μg/mg protein lysate. Western blotting: 1-2 μg/mL for 2hrs at RT. Immunohistology (Formalin/Paraffin): Use at 1/50 for 30 min. Staining of formalin-fixedtissue requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for for 10-20 minfollowed by cooling at RT foir 20 min. Positive Control. Raji, PC12 cells, Colon carcinoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
浓度 0.2 mg/mL
缓冲液 10 mM PBS, pH 7.4 containing 0.2 % BSA as stabilizer and 0.09 % Sodium Azide as preservative.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
有效期 12 months
厂商提供的图像
Immunohistochemistry (IHC) image for anti-CDKN1A 抗体 (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1)) (AA 1-80) (ABIN180466) anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 1-80), (N-Term) antibody
背景 Chen, Cipriano, Sarkar, Ware, Arenkiel: "P53-independent induction of p21(waf1) pathway is preserved during tumor progression." in: International journal of oncology, Vol. 7, Issue 4, pp. 889-93, 2011 (PubMed).

Buckley, Sweeney, Hamilton, Sini, Manning, Nicholson, deFazio, Watts, Musgrove, Sutherland: "Expression and amplification of cyclin genes in human breast cancer." in: Oncogene, Vol. 8, Issue 8, pp. 2127-33, 1993 (PubMed).