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ERK1/2 抗体

MAPK1/3 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 3F8 unconjugated
产品编号 ABIN1724731
发货至: 中国
  • 抗原 See all ERK1/2 (MAPK1/3) 抗体
    ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
    适用
    • 192
    • 162
    • 160
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    • 18
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    • 2
    • 2
    • 1
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    人, 小鼠
    宿主
    • 144
    • 50
    • 4
    小鼠
    克隆类型
    • 140
    • 58
    单克隆
    标记
    • 97
    • 12
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    • 8
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    This ERK1/2 antibody is un-conjugated
    应用范围
    • 155
    • 65
    • 51
    • 50
    • 49
    • 38
    • 24
    • 23
    • 22
    • 13
    • 4
    • 4
    • 3
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human MAPK expressed in E. coli.
    克隆位点
    3F8
    亚型
    IgG2b
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Lønne, Masoumi, Lennartsson, Larsson: "Protein kinase Cdelta supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33456-65, (2009) (PubMed).

  • 抗原
    ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
    别名
    p44/42 MAPK (Erk1/2) (MAPK1/3 产品)
    别名
    erk1/2 antibody, mitogen-activated protein kinase antibody, erk1/2 antibody
    背景

    Description: Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors such as U0126 and PD98059.

    Aliases: ERK, p38, p40, p41, ERK2, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk, MAPK1

    分子量
    42 kDa
    基因ID
    5594
    HGNC
    5594
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