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- 抗原 See all Src 抗体
- Src (Proto-oncogene tyrosine-protein kinase Src (Src))
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抗原表位
- AA 10-193
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Src antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- purified
- 免疫原
- Purified recombinant fragment of SRC (aa10-193) expressed in E. coli.
- 克隆位点
- 4F1E8
- 亚型
- IgG2b
- Top Product
- Discover our top product Src Primary Antibody
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- 应用备注
- ELISA: 1:10000, WB: 1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- 4°C, -20°C for long term storage
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FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5." in: Journal of cell science, Vol. 119, Issue Pt 1, pp. 47-55, (2005) (PubMed).
: "c-Src regulates constitutive and EGF-mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK." in: Pancreas, Vol. 31, Issue 3, pp. 263-74, (2005) (PubMed).
: "SRC tyrosine kinase inhibitor, m475271, suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation, invasion, and vascularization of human lung adenocarcinoma ..." in: Clinical & experimental metastasis, Vol. 22, Issue 3, pp. 195-204, (2005) (PubMed).
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FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5." in: Journal of cell science, Vol. 119, Issue Pt 1, pp. 47-55, (2005) (PubMed).
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- 抗原
- Src (Proto-oncogene tyrosine-protein kinase Src (Src))
- 别名
- SRC (Src 产品)
- 物质类
- Viral Protein
- 背景
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Description: SRC: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian). This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Aliases: ASV, SRC1, c-SRC, p60-Src
- 基因ID
- 6714
- HGNC
- 6714
- 途径
- JAK/STAT Signaling, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
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