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IGF1R-beta 抗体

适用: 人 IHC, ELISA, WB 宿主: 小鼠 Monoclonal 3C8B1 unconjugated
产品编号 ABIN1724670
发货至: 中国
  • 抗原
    IGF1R-beta
    适用
    宿主
    小鼠
    克隆类型
    单克隆
    应用范围
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of IGF1R-Beta expressed in E. coli.
    克隆位点
    3C8B1
    亚型
    IgG2b
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Scheidegger, Cenni, Picard, Delafontaine: "Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects." in: The Journal of biological chemistry, Vol. 275, Issue 49, pp. 38921-8, (2001) (PubMed).

    Adams, Epa, Garrett, Ward: "Structure and function of the type 1 insulin-like growth factor receptor." in: Cellular and molecular life sciences : CMLS, Vol. 57, Issue 7, pp. 1050-93, (2000) (PubMed).

  • 抗原
    IGF1R-beta
    背景

    Description: IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.

    Aliases: IGF1R, IGF1R-Beta

    分子量
    96 kDa
    基因ID
    3480
    HGNC
    3480
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