TLE4 抗体 (AA 681-773) (HRP)
-
- 抗原 See all TLE4 抗体
- TLE4 (Transducin-like Enhancer Protein 4 (TLE4))
-
抗原表位
- AA 681-773
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This TLE4 antibody is conjugated to HRP
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human TLE4
- 亚型
- IgG
- Top Product
- Discover our top product TLE4 Primary Antibody
-
anti-Transducin-like Enhancer Protein 4 (TLE4) (AA 1-773) antibody
TLE4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (N-Term) antibodyTLE4 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (AA 284-394) antibodyTLE4 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) antibodyTLE4 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (Internal Region) antibodyTLE4 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (AA 161-210) antibodyTLE4 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (AA 215-264) antibodyTLE4 适用: 人, 大鼠, 小鼠, 小鸡, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (N-Term) antibodyTLE4 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transducin-like Enhancer Protein 4 (TLE4) (Center) antibodyTLE4 适用: 人, 大鼠, 小鼠, 小鸡 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
-
- 抗原
- TLE4 (Transducin-like Enhancer Protein 4 (TLE4))
- 别名
- TLE4 (TLE4 产品)
- 背景
-
Synonyms: B lymphocyte gene 1, B lymphocyte gene 1, enhancer of split groucho 4, enhancer of split groucho 4, ESG4, ESG4, KIAA1261, TIM, TIM1, timeless Drosophila homolog, TLE4, transducin-like enhancer of split 4, transducin-like enhancer of split 4, TLE4_HUMAN.
Background: The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases.
- 基因ID
- 7091
- 途径
- WNT signaling
-
