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GLTSCR2 抗体 (AA 401-478) (HRP)

GLTSCR2 适用: 小鼠 WB, ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal HRP
产品编号 ABIN1712325
发货至: 中国
  • 抗原 See all GLTSCR2 products
    GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2 (GLTSCR2))
    抗原表位
    • 14
    • 8
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 401-478
    适用
    • 21
    • 14
    • 1
    • 1
    小鼠
    宿主
    • 29
    • 5
    • 1
    克隆类型
    • 33
    • 2
    多克隆
    标记
    • 12
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GLTSCR2 antibody is conjugated to HRP
    应用范围
    • 34
    • 18
    • 13
    • 13
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    小鼠
    预测反应
    Human,Rat,Dog,Cow,Sheep,Pig,Horse
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human GLTSCR2/PICT1
    亚型
    IgG
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    注意事项
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    GLTSCR2 (Glioma Tumor Suppressor Candidate Region Gene 2 (GLTSCR2))
    别名
    GLTSCR2/PICT1 (GLTSCR2 产品)
    别名
    GLTSCR2 antibody, pict1 antibody, pict-1 antibody, MGC115044 antibody, PICT-1 antibody, PICT1 antibody, 5330430H08Rik antibody, 9430097C02Rik antibody, AU041936 antibody, AW536441 antibody, R74911 antibody, NOP53 ribosome biogenesis factor antibody, NOP53 ribosome biogenesis factor L homeolog antibody, Nop53 antibody, NOP53 antibody, nop53 antibody, nop53.L antibody
    背景

    Synonyms: Glioma tumor suppressor candidate region gene 2 protein, GLTSCR2, GSCR2_HUMAN, p60, PICT1, protein interacting with carboxyl terminus 1.

    Background: The tumor suppressor PTEN plays an essential role in regulating signaling pathways involved in cell growth and apoptosis and is inactivated in a wide variety of tumors. Protein interacting with PTEN carboxyl terminus 1 (PICT-1), also designated p60 or Glioma tumor suppressor candidate region gene 2 protein, binds to the C-terminus of PTEN and regulates its turnover. Five Ser/Thr residues within the C-terminal segment of PTEN, including Ser-380, are phosphorylated upon binding of PTEN to PICT-1 and may contribute to the stabilization of PTEN. PICT-1 is localized to the nucleus and/or nucleolus and is highly expressed in pancreas and heart, but can also be detected in liver, skeletal muscle, placenta and kidney. PICT-1 also interacts with herpes simplex virus 1 regulatory proteins ICP22 and ICP0. The tumor suppressor GLTSCR2 gene, which encodes PICT-1, is located in a 150-kb minimal common deletion region for human gliomas, especially oligodendrogliomas, and maps to human chromosome 19q13.3.

    基因ID
    29997
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