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IL-10 抗体

IL10 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1685164
发货至: 中国
  • 抗原 See all IL-10 (IL10) 抗体
    IL-10 (IL10) (Interleukin 10 (IL10))
    适用
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    人, 小鼠, 大鼠
    宿主
    • 123
    • 62
    • 50
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    克隆类型
    • 127
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    多克隆
    标记
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    This IL-10 antibody is un-conjugated
    应用范围
    • 166
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    纯化方法
    Purified
    过滤
    Sterile filtered
    免疫原
    Polyclonal Interleukin-10 antibody was produced from sera of rabbits immunized with synthetic protein containing Interleukin-10 antigenic determinants.
    亚型
    IgG
    Top Product
    Discover our top product IL10 Primary Antibody
  • 应用备注
    ELISA: Use at a concentration range of 1-2 µg/mL.
    Western blot: A suitable range of concentrations of this antibody for WB detection is 10 µg/mL.
    IHC: A suitable range of concentrations of this antibody for IHC is 10 µg/mL.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
    缓冲液
    PBS solution at a concentration of 1 mg/mL.
    注意事项
    Avoid repeated freeze/thaw cycles.
    储存条件
    -20 °C
    储存方法
    Recombinant CD80, as supplied, can be stored in working aliquots at - 8 °C for one month, or at -20 °C to -70 °C for twelve months.
    有效期
    12 months
  • 抗原
    IL-10 (IL10) (Interleukin 10 (IL10))
    别名
    IL-10 (IL10 产品)
    背景
    CD80 is a monomeric surface protein found on activated APCs. The extracellular region of CD80 consists of two highly glycosylated Ig-like extracellular domains, which have defined regions for binding its ligands, CD28 or CTLA-4, on T cells. One ligand of CD80, CD28, provides critical costimulatory signals to activated T cells to increase cytokine production, cell proliferation, and cell viability, while the other ligand, CTLA-4, may mediate a growth-inhibitory signal. The same regions of CD80 are involved in binding to both CD28 and CTLA-4, but CTLA-4 binds to CD80 with about a0-fold higher avidity than CD28 does. This suggests that low levels of CTLA-4 expressed on the cell surface can compete for CD80 binding even when CD28 is expressed at much higher levels.
    UniProt
    P22301
    途径
    Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints
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