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GFRA1 抗体 (Extracellular Domain)

GFRA1 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal 3H8 unconjugated
产品编号 ABIN1449286
发货至: 中国
  • 抗原 See all GFRA1 抗体
    GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))
    抗原表位
    • 16
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 24-440, Extracellular Domain
    适用
    • 55
    • 37
    • 19
    • 16
    宿主
    • 50
    • 5
    • 2
    小鼠
    克隆类型
    • 52
    • 5
    单克隆
    标记
    • 28
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GFRA1 antibody is un-conjugated
    应用范围
    • 43
    • 16
    • 14
    • 13
    • 13
    • 13
    • 10
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP)
    特异性
    This antibody detects GFRα1. reacts with HCC-1500, MCF-7, but NOT with BT-20, ZR-75-1.
    交叉反应 (详细)
    Species reactivity (tested):Human
    纯化方法
    Protein A agarose
    免疫原
    Recombinant human GFRalpha1 extracellular domain (24-440 aa)
    克隆位点
    3H8
    亚型
    IgG2b
    Top Product
    Discover our top product GFRA1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
    储存液
    Without preservative
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Upon receipt, store (in aliqouts) at -20 °C.
  • 抗原
    GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))
    别名
    GFRA1 / GDNFR-alpha (GFRA1 产品)
    别名
    gdnfr antibody, ret1l antibody, retl1 antibody, trnr1 antibody, gdnfra antibody, MGC122616 antibody, gfr-alpha-1 antibody, GDNFR antibody, GDNFRA antibody, GFR-ALPHA-1 antibody, RET1L antibody, RETL1 antibody, TRNR1 antibody, GDNFRALPHA antibody, GFRA1 antibody, AU042498 antibody, gfralpha1a antibody, zgc:110129 antibody, GDNF family receptor alpha 1 antibody, glial cell line derived neurotrophic factor family receptor alpha 1 antibody, gdnf family receptor alpha 1a antibody, gfra1 antibody, GFRA1 antibody, Gfra1 antibody, gfra1a antibody
    背景
    Glial cell line-derived neurotrophic factor (GDNF) family plays a critical role in neurodevelopment and survival of central and peripheral neurons. The biological activity of GDNF family through receptor protein tyrosine kinase Ret and require a ligand specific co-receptor a (GFRa1, binds GDNF, whereas GFRa2 binds NRTN, GFRa3 binds ARTN and GFRa4 binds PSPN). Human GFRa1 is constituted from 465 amino acids and attach to the cell membrane by glycosylphosphatidylinositol (GPI) anchoring manner. It is widely accepted that homodimeric GDNF induce the complex formation of GFRa1 and further the stoichiometry of the signaling complex with GDNF2-GFRa12-Ret2, but the mechanism of complex formation remain unclear.Synonyms: GDNF family receptor alpha-1, GDNF receptor alpha, GDNFRA, GFR-alpha-1, RET ligand 1, RETL1, TGF-beta-related neurotrophic factor receptor 1, TRNR1
    基因ID
    2674
    NCBI登录号
    NP_001138925
    UniProt
    P56159
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