Cytochrome B-245, alpha Polypeptide (CYBA) 抗体 (PE)

ABIN1449195 产品详细信息, 供应商: Log in to see
抗原
  • zgc:66077
  • MGC80750
  • CYBA
  • p22-phox
  • p22phox
  • p22-PHOX
  • b558
  • nmf333
  • P22-PHOX
  • cytochrome b-245, alpha polypeptide
  • cytochrome b-245 light chain-like
  • p22-phox
  • cyba
  • CYBA
  • LOC101328418
  • Cyba
适用
人, 猴
49
23
23
4
2
2
1
1
1
1
宿主
小鼠
45
4
克隆类型 (克隆位点)
单克隆 ()
标记
PE
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
应用范围
Flow Cytometry (FACS)
32
18
16
13
5
4
3
2
1
1
1
选项
Supplier
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Supplier Product No.
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免疫原 Human cytochrome b-rich fraction
克隆位点 7D5
亚型 IgG1
特异性 This antibody recognizes the extracellular peptide portion of primate gp91phox of the Flavocytochrome b558.
无交叉反应 小鼠
交叉反应 (详细) Species reactivity (tested):Human, Monkey.
纯化方法 Protein A agarose
别名 Cytochrome B-245 Light Chain (CYBA Antibody 摘要)
背景 The NADPH oxidase is a multicomponent enzyme that transfers electrons from NADPH to O2 to generate superoxide (O2 -), a key part of the phagocytic or neutrophilic respiratory burst response. Flavocytochrome b558 is the catalytic component of the phagocyte NADPH oxidase. It is a transmembrane heterodimer composed of a large glycoprotein, gp91phox (PHagocyte OXidase) and a smaller protein, p22phox. Upon cell stimulation, flavocytochrome b558 assembles with p67phox, p47phox, and the GTP-binding protein Rac and becomes activated to generate O2 -. Mutations in gp91phox, p22phox, or other components of the NADPH oxidase can result in chronic granulomatous disease, which is associated with significant morbidity and mortality due to a predisposition to recurrent bacterial and fungal infections.Synonyms: CYBA, Cytochrome b(558) alpha chain, Cytochrome b558 subunit alpha, Neutrophil cytochrome b 22 kDa polypeptide, Superoxide-generating NADPH oxidase light chain subunit, p22 phagocyte B-cytochrome, p22-phox
基因ID 1535
NCBI登录号 NP_000092
UniProt P13498
途径 Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
缓冲液 PBS, 0.09 % NaN3, 1 % BSA
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C
储存方法 Store at 2-8 °C.
厂商提供的图像
Flow Cytometry (FACS) image for anti-Cytochrome B-245, alpha Polypeptide (CYBA) antibody (PE) (ABIN1449195) anti-Cytochrome B-245, alpha Polypeptide (CYBA) antibody (PE)
背景 Zhu, Marchal, Casbon, Stull, von Löhneysen, Knaus, Jesaitis, McCormick, Nauseef, Dinauer: "Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity." in: The Journal of biological chemistry, Vol. 281, Issue 41, pp. 30336-46, 2006 (PubMed).

Li, Grunwald, Mathieu, Morel, Stasia: "Crucial role of two potential cytosolic regions of Nox2, 191TSSTKTIRRS200 and 484DESQANHFAVHHDEEKD500, on NADPH oxidase activation." in: The Journal of biological chemistry, Vol. 280, Issue 15, pp. 14962-73, 2005 (PubMed).

Allen, Beecher, Lynch, Rohner, Wittine: "Helicobacter pylori disrupts NADPH oxidase targeting in human neutrophils to induce extracellular superoxide release." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 6, pp. 3658-67, 2005 (PubMed).

Carlyon, Abdel-Latif, Pypaert, Lacy, Fikrig: "Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection." in: Infection and immunity, Vol. 72, Issue 8, pp. 4772-83, 2004 (PubMed).

Brenner, Whiting-Theobald, Linton, Holmes, Anderson-Cohen, Kelly, Vanin, Pilon, Bodine, Horwitz, Malech: "Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells." in: Blood, Vol. 102, Issue 8, pp. 2789-97, 2003 (PubMed).

Burritt, Foubert, Baniulis, Lord, Taylor, Mills, Baughan, Roos, Parkos, Jesaitis: "Functional epitope on human neutrophil flavocytochrome b558." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6082-9, 2003 (PubMed).

Carlyon, Chan, Galán, Roos, Fikrig: "Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 12, pp. 7009-18, 2002 (PubMed).

Morgan, Cherny, Price, Dinauer, DeCoursey: "Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components." in: The Journal of general physiology, Vol. 119, Issue 6, pp. 571-80, 2002 (PubMed).

Kurosaka, Ishida, Yamamura, Takase, Otani, Kumon: "A non-surgical rat model of foreign body-associated urinary tract infection with Pseudomonas aeruginosa." in: Microbiology and immunology, Vol. 45, Issue 1, pp. 9-15, 2001 (PubMed).

Kornberg: "Remembering our teachers." in: The Journal of biological chemistry, Vol. 276, Issue 1, pp. 3-11, 2001 (PubMed).

Yu, Cross, Zhen, Dinauer: "Functional analysis of NADPH oxidase in granulocytic cells expressing a delta488-497 gp91(phox) deletion mutant." in: Blood, Vol. 94, Issue 7, pp. 2497-504, 1999 (PubMed).

Yu, Quinn, Cross, Dinauer: "Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 14, pp. 7993-8, 1998 (PubMed).

Strader, Gaffney, Sugg, Candelore, Keys, Patchett, Dixon: "Allele-specific activation of genetically engineered receptors." in: The Journal of biological chemistry, Vol. 266, Issue 1, pp. 5-8, 1991 (PubMed).

Verhoeven, Bolscher, Meerhof, van Zwieten, Keijer, Weening, Roos: "Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils." in: Blood, Vol. 73, Issue 6, pp. 1686-94, 1989 (PubMed).

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