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LAMP2 抗体

LAMP2 适用: 人 IHC, FACS 宿主: 小鼠 Monoclonal H4B4 unconjugated
产品编号 ABIN135832
发货至: 中国
  • 抗原 See all LAMP2 抗体
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
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    小鼠
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    单克隆
    标记
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    This LAMP2 antibody is un-conjugated
    应用范围
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    Immunohistochemistry (IHC), Flow Cytometry (FACS)
    特异性
    Human/Rhesus/African Green Monkey CD107b, Mr 100-120 kDa
    产品特性
    Mouse Anti-Human CD107b-UNLB
    纯化方法
    Purified
    免疫原
    Human adherent peripheral blood cells
    克隆位点
    H4B4
    亚型
    IgG1
    Top Product
    Discover our top product LAMP2 Primary Antibody
  • 应用备注
    Working Dilution:
    FACS: 1 µg/10^6 cells
    Representative data are included in this product insert.

    Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
    样本量
    1 mL
    限制
    仅限研究用
  • 缓冲液
    Product is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.
    注意事项
    Each reagent is stable for the period shown on the bottle label if stored as directed.
    储存条件
    4 °C
  • Eriksson, Wäster, Öllinger: "Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins." in: Cell death & disease, Vol. 11, Issue 5, pp. 370, (2020) (PubMed).

    Wäster, Eriksson, Vainikka, Rosdahl, Öllinger: "Extracellular vesicles are transferred from melanocytes to keratinocytes after UVA irradiation." in: Scientific reports, Vol. 6, pp. 27890, (2016) (PubMed).

    Boman, Svensson, Boxer, Rojas, Seeley, Karydas, Miller, Kågedal, Svenningsson: "Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid." in: Journal of Parkinson's disease, Vol. 6, Issue 2, pp. 307-15, (2016) (PubMed).

    Fritsch, Stephan, Tchikov, Winoto-Morbach, Gubkina, Kabelitz, Schütze: "Cell Fate Decisions to TNF Regulated by K63 Ubiquitination of TNF-Receptor 1." in: Molecular and cellular biology, (2014) (PubMed).

    Armstrong, Mattsson, Appelqvist, Janefjord, Sandin, Agholme, Olsson, Svensson, Blennow, Zetterberg, Kågedal: "Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease." in: Neuromolecular medicine, Vol. 16, Issue 1, pp. 150-60, (2014) (PubMed).

  • 抗原
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    别名
    CD107b (LAMP2 产品)
    别名
    CD107b antibody, LAMP-2 antibody, LAMPB antibody, LGP110 antibody, Lamp-2 antibody, Lamp-2a antibody, Lamp-2b antibody, Lamp-2c antibody, Mac3 antibody, cd107b antibody, lamp-2 antibody, lampb antibody, LAMP2 antibody, lamp2 antibody, DKFZp459J126 antibody, LGP-B antibody, sb:cb587 antibody, wu:fb14a06 antibody, zgc:103532 antibody, lysosomal associated membrane protein 2 antibody, lysosomal-associated membrane protein 2 antibody, lysosomal-associated membrane protein 2 S homeolog antibody, lysosomal membrane glycoprotein 2 antibody, LAMP2 antibody, Lamp2 antibody, lamp2.S antibody, lamp2 antibody
    背景
    CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.
    途径
    Autophagy
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