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CD8 alpha 抗体

Name: CD8 alpha 抗体
Brand: antibodies-online
SKU: ABIN135118
Availability: OutOfStock

CD8A 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal 53-6-7 unconjugated

BALB/c mouse splenocytes were stained with Rat Anti-Mouse CD8α-UNLB.

FACS

Image no. 1 for anti-CD8a Molecule (CD8A) antibody (ABIN135118)

2 images

(1 reference)

产品编号 ABIN135118

发货至: 中国

Datasheet as PDF

抗原 See all CD8 alpha (CD8A) 抗体

CD8 alpha (CD8A) (CD8a Molecule (CD8A))
适用
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小鼠
宿主
144

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大鼠
Compatible Secondaries
克隆类型
270

100

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单克隆
标记
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This CD8 alpha antibody is un-conjugated
应用范围
288

105

92

66

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Flow Cytometry (FACS)

特异性

Mouse CD8α, Mr 32-34 kDa

产品特性

Rat Anti-Mouse CD8a-UNLB

纯化方法

Purified

免疫原

Spleen cells or thymocyte membranes

克隆位点

53-6-7

亚型

IgG2a

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anti-CD8a Molecule (CD8A) antibody
CD8A 适用: 人 IHC, WB, IP, ELISA 宿主: 兔 Monoclonal 2F2 unconjugated Recombinant Antibody

anti-CD8a Molecule (CD8A) antibody
CD8A 适用: 小鼠 FACS, IP, IHC (fro), IHC (p), ICC 宿主: 大鼠 Monoclonal 53-6-7 unconjugated

anti-CD8a Molecule (CD8A) antibody
CD8A 适用: 小鼠 FACS, IP, IHC (fro), IHC (p), ICC, Func 宿主: 大鼠 Monoclonal 53-6-7 unconjugated

anti-CD8a Molecule (CD8A) antibody (FITC)
CD8A 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal 53-6-7 FITC

anti-CD8a Molecule (CD8A) antibody
CD8A 适用: 人 IHC, StM, ISt 宿主: 小鼠 Monoclonal C8-468 unconjugated

anti-CD8a Molecule (CD8A) (N-Term) antibody
CD8A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-CD8a Molecule (CD8A) (C-Term) antibody
CD8A 适用: 人 FACS, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-CD8a Molecule (CD8A) antibody (PE)
CD8A 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal 53-6-7 PE

应用备注
- Applications: FC - Quality tested , IHC-FS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , Depletion - Reported in literature , Block - Reported in literature
- Working Dilutions: Flow Cytometry Purified (UNLB) antibody 2 g/106 cells FITC and BIOT conjugates 2 g/106 cells AF488 conjugate 1 g/106 cells PE, APC, SPRD, PE/TXRD, CY5, PE/CY5.5, PE/CY7, 0.2 g/106 cells APC/CY5.5, APC/CY7, PACBLU, AF647, and AF700 conjugates For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
说明

In vivo and in vitro depletion of CD8a+ cells

样本量

1 mL

限制

仅限研究用
浓度

0.5 mg/mL

缓冲液

0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

储存液

Without preservative

注意事项

Each reagent is stable for the period shown on the bottle label if stored as directed.

储存条件

4 °C

储存方法

Store at 2-8°C
Jordan, Buhrman, Sprague, Moore, Gao, Kappler, Slansky: "TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines." in: Cancer immunology, immunotherapy : CII, (2012) (PubMed).
抗原

CD8 alpha (CD8A) (CD8a Molecule (CD8A))

别名

CD8a (CD8A 产品)

别名

cd8 antibody, LOC100136450 antibody, BB154331 antibody, Ly-2 antibody, Ly-35 antibody, Ly-B antibody, Lyt-2 antibody, zgc:136643 antibody, CD8 antibody, Leu2 antibody, MAL antibody, p32 antibody, RHACD8-4 antibody, CD8a molecule antibody, uncharacterized LOC100125537 antibody, CD8 alpha antibody, CD8 antigen, alpha chain antibody, T-cell surface glycoprotein CD8 alpha chain antibody, Cd8a antibody, LOC100125537 antibody, LOC100136450 antibody, CD8A antibody, cd8a antibody, LOC100126556 antibody

背景

In the mouse, CD8 exists in two forms: (i) a CD8 heterodimer composed of an chain (CD8/Lyt-2) and a chain (CD8/Lyt-3), and (ii) a homodimer of two chains. The heterodimer is found on the surface of essentially all thymocytes and the suppressor/cytotoxic subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8 without CD8. It has been suggested that CD8+- T cells mature extrathymically, while development of the CD8++ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8+ cells.

途径

TCR Signaling