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LYVE1 抗体 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1) (AA 24-232) (Biotin)

Details for Product anti-LYVE1 Antibody No. ABIN126136, 供应商: Log in to see
抗原
  • LYVE1
  • XLKD1
  • CRSBP-1
  • HAR
  • LYVE-1
  • 1200012G08Rik
  • Crsbp-1
  • Lyve-1
  • Xlkd1
  • lymphatic vessel endothelial hyaluronic acid receptor 1-like
  • lymphatic vessel endothelial hyaluronan receptor 1
  • LOC560618
  • LOC100347960
  • LYVE1
  • Lyve1
Alternatives
anti-人 LYVE1 抗体 for ELISA
抗原表位
AA 24-232
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3
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适用

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2
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宿主

158
59
58
3
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1
克隆类型
多克隆
标记
This LYVE1 antibody is conjugated to Biotin
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应用范围
Flow Cytometry (FACS)
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42
34
28
13
11
2
1
1
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免疫原 Recombinant Human soluble LYVE-1 (24-232) produced in insect cells. Remarks: The recombinant soluble LYVE-1 consists of amino acid 24 (Ser) to 232 (Gly) and is fused to a C-terminal His-tag (6xHis).
特异性 The antibody recognizes LYVE-1.
纯化方法 Antigen Affinity Chromatography.
别名 LYVE-1 (LYVE1 Antibody 摘要)
背景 LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41 % similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 Molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 Molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.Synonyms: CRSBP-1, CRSBP1, Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, HAR, Hyaluronic acid receptor, LYVE1, Lymphatic vessel endothelial hyaluronic acid receptor 1, XLKD1
基因ID 10894
NCBI登录号 NP_006682
UniProt Q9Y5Y7
研究领域 Enzymes
途径 Glycosaminoglycan Metabolic Process
应用备注 The unconjugated antibody can be used for ELISA experiments, Western blotting, FACSand Cell Sorting (Use at 2-5 μg/mL together with the appropriate secondary reagents).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
溶解方式 Restore with sterile water to a concentration of 50 μg/mL
缓冲液 0.1 M Tris-Cl, 0.1 M NaCl, pH 7.4 containing 0.02 % Sodium Azide as preservative and 50x BSA as stabilizer.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
背景 Jackson: "The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1." in: Trends in cardiovascular medicine, Vol. 13, Issue 1, pp. 1-7, 2003 (PubMed).

Mouta Carreira, Nasser, di Tomaso, Padera, Boucher, Tomarev, Jain: "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis." in: Cancer research, Vol. 61, Issue 22, pp. 8079-84, 2001 (PubMed).

Sleeman, Krishnan, Kirkin, Baumann: "Markers for the lymphatic endothelium: in search of the holy grail?" in: Microscopy research and technique, Vol. 55, Issue 2, pp. 61-9, 2001 (PubMed).