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ITGAL 抗体

ITGAL 适用: 人 FACS, IP, Func 宿主: 小鼠 Monoclonal MEM-25 unconjugated
产品编号 ABIN126003
发货至: 中国
  • 抗原 See all ITGAL 抗体
    ITGAL (Integrin alpha-L (ITGAL))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This ITGAL antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
    特异性
    The antibody clone MEM-25 reacts with the alpha-subunit (CD11a) of human LFA-1, a 170-180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
    纯化方法
    Protein A chromatography
    免疫原
    Leucocytes from a pacient suffering from a LGL-type leukaemia
    克隆位点
    MEM-25
    亚型
    IgG1
    Top Product
    Discover our top product ITGAL Primary Antibody
  • 应用备注
    Flow Cytometry. Immunoprecipitation (excellent for immunoaffinity purification of LFA-1 complex)). Functional applications (MAb MEM-25 partially blocks binding of LFA-1 complex to ICAM-1).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Azide free phosphate buffered saline (PBS), preserved by filter sterilization, approx. pH 7.4
    储存液
    Azide free
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Wang, Kwas, Wu: "Intercellular adhesion molecule 1 (ICAM-1), but not ICAM-2 and -3, is important for dendritic cell-mediated human immunodeficiency virus type 1 transmission." in: Journal of virology, Vol. 83, Issue 9, pp. 4195-204, (2009) (PubMed).

    Aubert, Yoon, Sloan, Spear, Jerome: "The virological synapse facilitates herpes simplex virus entry into T cells." in: Journal of virology, Vol. 83, Issue 12, pp. 6171-83, (2009) (PubMed).

  • 抗原
    ITGAL (Integrin alpha-L (ITGAL))
    别名
    CD11a / ITGAL (ITGAL 产品)
    别名
    CD11A antibody, LFA-1 antibody, LFA1A antibody, (p180) antibody, Cd11a antibody, LFA-1A antibody, Ly-15 antibody, Ly-21 antibody, CD11a antibody, ITGAL antibody, integrin subunit alpha L antibody, integrin alpha L antibody, ITGAL antibody, Itgal antibody
    背景
    CD11a together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation, binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.Synonyms: CD11 antigen-like family member A, Integrin alpha-L, LFA-1, LFA1, Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte function-associated molecule 1 alpha chain
    基因ID
    3683
    NCBI登录号
    NP_002200
    UniProt
    P20701
    途径
    Activated T Cell Proliferation, Integrin Complex
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