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LRP1 抗体

LRP1 适用: 人, 小鼠, 大鼠, 兔, Hamster WB, FACS, IF, IHC (fro) 宿主: 小鼠 Monoclonal 8B8 unconjugated
产品编号 ABIN125957
发货至: 中国
  • 抗原 See all LRP1 抗体
    LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
    适用
    • 101
    • 54
    • 52
    • 10
    • 4
    • 3
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    • 1
    • 1
    人, 小鼠, 大鼠, 兔, Hamster
    宿主
    • 93
    • 27
    • 1
    小鼠
    克隆类型
    • 86
    • 35
    单克隆
    标记
    • 44
    • 13
    • 9
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    • 4
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    • 4
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    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
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    This LRP1 antibody is un-conjugated
    应用范围
    • 64
    • 45
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    • 32
    • 21
    • 15
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    • 9
    • 9
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    • 1
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    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    8B8 specifically reacts with the 85 kDa β-chain of human LRP/α2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepato-cytes, tissue macrophages, subsets of neurones and as-trocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in athero-sclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).
    纯化方法
    Affinity Chromatography on Protein A.
    免疫原
    Human LRP/alpha2MR
    克隆位点
    8B8
    亚型
    IgG1
    Top Product
    Discover our top product LRP1 Primary Antibody
  • 应用备注
    Immunofluorescence. Immunohistochemistry: 1/20. Flow Cytometry. Immunoblotting.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 溶解方式
    Restore in 1 mL dist. water.
    缓冲液
    Final Solution contains PBS buffer, pH 7.4 containing 0.5 % BSA without preservatives.
    储存液
    Without preservative
    注意事项
    This product is photosensitive and should be protected from light
    储存条件
    4 °C
    储存方法
    Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
  • 抗原
    LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
    别名
    CD91 / LRP1 (LRP1 产品)
    别名
    A2MR antibody, APOER antibody, APR antibody, CD91 antibody, IGFBP3R antibody, LRP antibody, LRP1A antibody, TGFBR5 antibody, A2mr antibody, AI316852 antibody, Lrp antibody, LRP-1 antibody, LDL receptor related protein 1 antibody, prolow-density lipoprotein receptor-related protein 1 antibody, low density lipoprotein receptor-related protein 1 antibody, LRP1 antibody, Lrp1 antibody, LOC100414789 antibody
    背景
    Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.Synonyms: A2MR, APOER, APR, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1
    基因ID
    4035
    NCBI登录号
    NP_002323
    UniProt
    Q07954
    途径
    Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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