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Factor VIII 抗体

F8 适用: 人, Pig WB, EIA, RIA 宿主: 小鼠 Monoclonal RFFVIIIC-8 unconjugated
产品编号 ABIN120341
发货至: 中国
  • 抗原 See all Factor VIII (F8) 抗体
    Factor VIII (F8) (Coagulation Factor VIII (F8))
    适用
    • 94
    • 59
    • 30
    • 17
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    人, Pig
    宿主
    • 88
    • 20
    • 4
    • 2
    小鼠
    克隆类型
    • 95
    • 19
    单克隆
    标记
    • 49
    • 15
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This Factor VIII antibody is un-conjugated
    应用范围
    • 54
    • 42
    • 39
    • 39
    • 24
    • 11
    • 10
    • 10
    • 10
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA), Radioimmunoassay (RIA)
    特异性
    Clone RFFVIIIC/8 is a very potent coagulation inhibitor. This antibody recognizes an epitope towards the N-terminus of full length Factor VIII. It also recognises the 210 kDa, 90 kDa and 40 kDa cleavage products. This clone does not cross-react with von Willebrand factor.
    无交叉反应
    小鼠, 犬, 大鼠
    交叉反应 (详细)
    Species reactivity (tested):Human and Pig.
    纯化方法
    Affinity Chromatography on Protein G from tissue culture supernatant
    免疫原
    Affinity purified Human Factor VIII
    克隆位点
    RFFVIIIC-8
    亚型
    IgG1
    Top Product
    Discover our top product F8 Primary Antibody
  • 应用备注
    ELISA: 1:200 - 1:2000. Western blotting: 1:20 - 1:200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, 0.09 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    Factor VIII (F8) (Coagulation Factor VIII (F8))
    Abstract
    F8 产品
    别名
    fb61d02 antibody, wu:fb61d02 antibody, Cf-8 antibody, Cf8 antibody, FVIII antibody, AHF antibody, DXS1253E antibody, F8B antibody, F8C antibody, HEMA antibody, coagulation factor VIIi antibody, coagulation factor VIII antibody, coagulation factor VIII, procoagulant component antibody, f7i antibody, F8 antibody
    背景
    Human Factor VIII is an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and crosslinks to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause haemophilia A, a disorder characterised by the body's inability to control blood clotting. This could result in severe blood loss, even with minor injuries.Synonyms: AHF, Antihemophilic factor, F8C, Procoagulant component
    基因ID
    2157
    NCBI登录号
    NP_000123
    UniProt
    P00451
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