(6 references)-
- 抗原 See all CD45 (PTPRC) 抗体
- CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
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适用
- 人, 灵长类
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD45 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- The antibody MEM-55 recognizes a siliadase-sensitive epitope of CD45RB, a 180-240 kDa single chain type I membrane glycoprotein, variant of CD45 (CD45RB isoform). CD45RB is expressed on a subset of T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells.
- 交叉反应 （详细）
- Species reactivity (tested):Human, non-Human Primates.
- 纯化方法
- Affinity Chromatography on Protein A
- 免疫原
- Human thymocytes and T lymphocytes
- 克隆位点
- MEM-55
- 亚型
- IgG1
- Top Product
- Discover our top product PTPRC Primary Antibody
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anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 1210-1304) antibody
PTPRC 适用: 人, 小鼠, 大鼠, 兔 FACS, WB, IHC (p), ELISA, IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibodyPTPRC 适用: 人, 犬 FACS, IHC, WB, StM 宿主: 小鼠 Monoclonal 2B11-PD7-26 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 193-575) antibodyPTPRC 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 371-556) antibodyPTPRC 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 24-575) antibodyPTPRC 适用: 人 FACS, IHC, WB, IF, ELISA 宿主: 小鼠 Monoclonal 17H9D4 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (C-Term) antibodyPTPRC 适用: 人, 小鼠, 大鼠, 犬, 小鸡, Cow, Cat, 兔, 绵羊, Pig, 豚鼠, 山羊, 马, 猴, Hamster, 驴, Avian WB 宿主: 山羊 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibodyPTPRC 适用: 人 FACS, IHC, WB, IF, StM 宿主: 兔 Monoclonal PTPRC-2877R unconjugated Recombinant Antibody
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) antibodyPTPRC 适用: 人 FACS, WB, IP, IHC (p), ICC 宿主: 小鼠 Monoclonal MEM-28 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 378-577) antibodyPTPRC 适用: 人, 小鼠, 大鼠 FACS, IHC, WB, ELISA, ICC 宿主: 小鼠 Monoclonal 2H3E2 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) (AA 431-577) antibodyPTPRC 适用: 人 FACS, IHC, WB, ELISA, ICC, Neut 宿主: 小鼠 Monoclonal 7C9F12 unconjugated
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- 应用备注
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Flow Cytometry. Immunoprecipitation. Western Blotting. Immunohistochemistry (FFPE sections). No pre-treatment of tissue sections is essential.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS, pH ~7.4, 15 mM Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing. Do not freeze working dilutions.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the original vial at 2-8 °C. Freeze stock solution or aliquots thereof at -20 °C.
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: "Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process." in: Scientific reports, Vol. 6, pp. 22586, (2017) (PubMed).
: "Functional expression of full-length TrkA in the prokaryotic host Magnetospirillum magneticum AMB-1 by using a magnetosome display system." in: Applied and environmental microbiology, Vol. 81, Issue 4, pp. 1472-6, (2016) (PubMed).
: "Pivotal advance: CD45RB glycosylation is specifically regulated during human peripheral B cell differentiation." in: Journal of leukocyte biology, Vol. 90, Issue 1, pp. 5-19, (2011) (PubMed).
: "Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 107, Issue 6, pp. 1943-50, (2010) (PubMed).
: "Targeted delivery of IFNgamma to tumor vessels uncouples antitumor from counterregulatory mechanisms." in: Cancer research, Vol. 65, Issue 7, pp. 2906-13, (2005) (PubMed).
: "Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies." in: Cancer letters, Vol. 61, Issue 3, pp. 255-62, (1992) (PubMed).
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: "Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process." in: Scientific reports, Vol. 6, pp. 22586, (2017) (PubMed).
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- 抗原
- CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))
- 别名
- CD45 / LCA (PTPRC 产品)
- 别名
- PTPRC antibody, si:dkeyp-47c5.1 antibody, B220 antibody, CD45 antibody, CD45R antibody, GP180 antibody, L-CA antibody, LCA antibody, LY5 antibody, T200 antibody, Cd45 antibody, Ly-5 antibody, Lyt-4 antibody, loc antibody, Lca antibody, RT7 antibody, cd45 antibody, protein tyrosine phosphatase, receptor type C antibody, protein tyrosine phosphatase, receptor type, C antibody, receptor-type tyrosine-protein phosphatase C antibody, PTPRC antibody, ptprc antibody, LOC100074271 antibody, Ptprc antibody
- 背景
- CD45RB is an of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed e.g. in microglia and inflammatory cells.Synonyms: L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
- 基因ID
- 5788
- NCBI登录号
- NP_002829
- UniProt
- P08575
- 途径
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling
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